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MK-801 potentiates dopaminergic D1 but reduces D2 responses in the 6-hydroxydopamine model of Parkinson's disease.

作者信息

Morelli M, Di Chiara G

机构信息

Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Italy.

出版信息

Eur J Pharmacol. 1990 Jul 17;182(3):611-2. doi: 10.1016/0014-2999(90)90066-f.

DOI:10.1016/0014-2999(90)90066-f
PMID:1977595
Abstract
摘要

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1
MK-801 potentiates dopaminergic D1 but reduces D2 responses in the 6-hydroxydopamine model of Parkinson's disease.
Eur J Pharmacol. 1990 Jul 17;182(3):611-2. doi: 10.1016/0014-2999(90)90066-f.
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Influence of previous exposure to levodopa on the interaction between dizocilpine and dopamine D1 and D2 agonists in rats with 6-hydroxydopamine-induced lesions.左旋多巴既往暴露对6-羟基多巴胺诱导损伤大鼠中地佐环平与多巴胺D1和D2激动剂相互作用的影响。
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Chronic levodopa impairs the recovery of dopamine agonist-induced rotational behavior following neural grafting.长期使用左旋多巴会损害神经移植后多巴胺激动剂诱导的旋转行为的恢复。
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Adenosine A2 receptors interact negatively with dopamine D1 and D2 receptors in unilaterally 6-hydroxydopamine-lesioned rats.
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Role of N-methyl-D-aspartate receptors in dopamine D1-, but not D2-, mediated changes in striatal and accumbens neurotensin systems.N-甲基-D-天冬氨酸受体在多巴胺D1介导而非D2介导的纹状体和伏隔核神经降压素系统变化中的作用。
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Supersensitization of intrastriatal dopamine receptors involved in opposite regulation of acetylcholine release in Parkinson's model rats.帕金森病模型大鼠纹状体内多巴胺受体的超敏化参与乙酰胆碱释放的反向调节
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Blockade ofNMDA receptors differentially affectsD-1 andD-2 mediated turning behavior in the 6-hydroxydopamine model of Parkinson.阻断 NMDA 受体在 6-羟多巴胺帕金森模型中对 D-1 和 D-2 介导的转向行为的影响不同。
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The muscarine antagonist methscopolamine and the NMDA antagonist AP-5 injected unilaterally into the nucleus accumbens cause mice to rotate in opposite directions.将毒蕈碱拮抗剂甲基东莨菪碱和NMDA拮抗剂AP - 5单侧注射到伏隔核中会使小鼠向相反方向旋转。
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