布伦斯特德酸促进的糖霉素二糖糖烯亚结构的糖基化反应。
Brønsted acid-promoted glycosylations of disaccharide glycal substructures of the saccharomicins.
作者信息
Balthaser Bradley R, McDonald Frank E
机构信息
Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA.
出版信息
Org Lett. 2009 Nov 5;11(21):4850-3. doi: 10.1021/ol901923x.
Abstract
An acid-promoted glycosylation and alkynol cycloisomerization sequence provided direct access to the 2-deoxytrisaccharide corresponding to the fucose-saccharosamine-digitoxose substructure of saccharomicin B. In the course of this work, the absolute stereochemistry of the repeating fucose-saccharosamine disaccharide of saccharomicins was also confirmed.
摘要
一种酸促进的糖基化和炔醇环异构化序列可直接得到对应于苦霉素B中岩藻糖-氨基糖-洋地黄毒糖亚结构的2-脱氧三糖。在这项工作过程中，苦霉素中重复的岩藻糖-氨基糖二糖的绝对立体化学也得到了确认。
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