Mahoney Martin C, Va Puthiery, Stevens Adrian, Kahn Amy R, Michalek Arthur M
Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
J Rural Health. 2009 Fall;25(4):378-83. doi: 10.1111/j.1748-0361.2009.00247.x.
This manuscript examines shifts in patterns of cancer incidence among the Seneca Nation of Indians (SNI) for the interval 1955-1969 compared to 1990-2004.
A retrospective cohort design was used to examine cancer incidence among the SNI during 2 time intervals: 1955-1969 and 1990-2004. Person-years at risk were multiplied by cancer incidence rates for New York State, exclusive of New York City, over 5-year intervals. A computer-aided match with the New York State Cancer Registry was used to identify incident cancers. Overall and site-specific standardized incidence ratios (SIRs = observed/expected x 100), and 95% confidence intervals (CIs), were calculated for both time periods.
During the earlier interval, deficits in overall cancer incidence were noted among males (SIR = 56, CI 36-82) and females (SIR = 71, CI 50-98), and for female breast cancers (SIR = 21, CI 4-62). During the more recent intervals, deficits in overall cancer incidence persisted among both genders (males SIR = 63, CI 52-77; females SIR = 67, CI 55-80). Deficits were also noted among males for cancers of the lung (SIR = 60, CI 33-98), prostate (SIR = 51, CI = 33-76) and bladder (SIR = 17, CI = 2-61) and among females for breast (SIR = 33, CI = 20-53) and uterus (SIR = 36, CI = 10-92). No cancer sites demonstrated increased incidence. Persons ages 60-69 years, 70-79 years, and ages 80+ years tended to exhibit deficits in overall incidence.
Despite marked changes over time, deficits in overall cancer incidence have persisted between the time intervals studied. Tribal-specific cancer data are important for the development and implementation of comprehensive cancer control plans which align with local needs.
本手稿研究了1955 - 1969年与1990 - 2004年期间，塞内卡印第安人部落（SNI）癌症发病率模式的变化。
采用回顾性队列设计，研究SNI在两个时间段（1955 - 1969年和1990 - 2004年）的癌症发病率。将风险人年数乘以纽约州（不包括纽约市）5年间隔期的癌症发病率。通过与纽约州癌症登记处进行计算机辅助匹配来识别新发癌症。计算两个时间段的总体和特定部位标准化发病率（SIR = 观察值/期望值×100）以及95%置信区间（CI）。
在较早时间段，男性（SIR = 56，CI 36 - 82）和女性（SIR = 71，CI 50 - 98）的总体癌症发病率存在不足，女性乳腺癌（SIR = 21，CI 4 - 62）也是如此。在较近时间段，两性的总体癌症发病率仍存在不足（男性SIR = 63，CI 52 - 77；女性SIR = 67，CI 55 - 80）。男性的肺癌（SIR = 60，CI 33 - 98）、前列腺癌（SIR = 51，CI = 33 - 76）和膀胱癌（SIR = 17，CI = 2 - 61）以及女性的乳腺癌（SIR = 33，CI = 20 - 53）和子宫癌（SIR = 36，CI = 10 - 92）也存在不足。没有癌症部位的发病率显示增加。60 - 69岁、70 - 79岁以及80岁及以上的人群总体发病率往往存在不足。
尽管随着时间推移有显著变化，但在所研究的时间段之间，总体癌症发病率的不足一直存在。特定部落的癌症数据对于制定和实施符合当地需求 的综合癌症控制计划很重要。
