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临床医生在初次诊断和评估时是否应常规确定鼻炎亚型?专家们展开了一场辩论。

Should clinicians routinely determine rhinitis subtype on initial diagnosis and evaluation? A debate among experts.

作者信息

Quan Martin, Casale Thomas B, Blaiss Michael S

机构信息

David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.

出版信息

Clin Cornerstone. 2009;9(3):54-60. doi: 10.1016/s1098-3597(09)80014-8.

Abstract

Rhinitis is one of the most prevalent conditions affecting Americans today. Twenty to 40 million Americans (10%-30% of adults and up to 40% of children) are estimated to have allergic rhinitis. In recent decades, its prevalence in Western societies has increased dramatically, and studies from around the world are reporting similar trends. Although studies have traditionally reported a 3:1 ratio of allergic to nonallergic rhinitis, recent data suggest that as many as 87% of patients with rhinitis may have mixed rhinitis, a combination of both allergic and nonallergic rhinitis. Untreated or inappropriately managed rhinitis can significantly affect a patient's quality of life and ability to perform activities of daily living. It is often associated with concomitant conditions, such as fatigue, headache, sleep disturbance, cognitive impairment, and respiratory conditions, complicated by rhinitis, including asthma and sinusitis. It is a significant cause of morbidity, health care expenditure, reduced work productivity, and absences from school. According to the recently released updated practice parameters, The Diagnosis & Management of Rhinitis, rhinitis is characterized by the presence of one or more of the following nasal symptoms: Congestion, Rhinorrhea (anterior and posterior), Sneezing, Itching. Inflammation is normally associated with rhinitis, but certain subtypes of the disease, such as vasomotor (increasingly known as chronic idiopathic rhinitis) or nonallergic rhinitis and atrophic rhinitis, are not predominantly inflammatory. The diagnosis of rhinitis may appear to be a fairly straightforward undertaking; however, rhinitis is composed of numerous subtypes and etiologies, and differentiating them can be a challenge for primary care practitioners. Further complicating matters is the fact that many patients have both an allergic and a nonallergic component to their rhinitis. Whether or not identification of rhinitis subtype should be an integral component of initial diagnosis remains an area of controversy. While standard treatment for allergic and nonallergic rhinitis is often the same, certain subtypes of the disease do not respond well to the usual first-line treatments for allergic rhinitis. Identification of subtype, therefore, can potentially have important implications for treatment choice. In the following section, we present a discussion between 2 members of the Respiratory & Allergic Disease (RAD) Foundation, Thomas B. Casale, MD, and Michael S. Blaiss, MD. Drs. Casale and Blaiss debate the question, "Should clinicians routinely determine rhinitis subtype on initial diagnosis and evaluation?" Each expert was randomly assigned a position to take: Dr. Casale's views represent the "pro" argument while Dr. Blaiss was asked to speak to the "con" argument. The debate concludes with a synthesis of their arguments and final points, including important takeaway messages for the primary care practitioner.

摘要

鼻炎是当今影响美国人的最常见病症之一。据估计,有2000万至4000万美国人(占成年人的10% - 30%,儿童中高达40%)患有过敏性鼻炎。近几十年来,其在西方社会的患病率急剧上升,世界各地的研究也都报告了类似趋势。尽管传统研究报告过敏性鼻炎与非过敏性鼻炎的比例为3:1,但最近的数据表明,高达87%的鼻炎患者可能患有混合性鼻炎,即过敏性鼻炎和非过敏性鼻炎的组合。未经治疗或管理不当的鼻炎会显著影响患者的生活质量和进行日常生活活动的能力。它常与伴随病症相关,如疲劳、头痛、睡眠障碍、认知障碍以及因鼻炎而复杂化的呼吸道疾病,包括哮喘和鼻窦炎。它是发病、医疗保健支出、工作效率降低和缺课的重要原因。根据最近发布的更新后的实践参数《鼻炎的诊断与管理》,鼻炎的特征是存在以下一种或多种鼻部症状:鼻塞、流涕(前后)、打喷嚏、瘙痒。炎症通常与鼻炎相关,但该疾病的某些亚型,如血管运动性鼻炎(越来越多地被称为慢性特发性鼻炎)或非过敏性鼻炎以及萎缩性鼻炎,并非以炎症为主。鼻炎的诊断看似是一项相当直接的任务;然而,鼻炎由众多亚型和病因组成,对初级保健医生来说,区分它们可能是一项挑战。更复杂的是,许多患者的鼻炎既有过敏性成分又有非过敏性成分。鼻炎亚型的识别是否应作为初始诊断的一个组成部分,仍是一个有争议的领域。虽然过敏性鼻炎和非过敏性鼻炎的标准治疗通常相同,但该疾病的某些亚型对过敏性鼻炎常用的一线治疗反应不佳。因此,亚型的识别可能对治疗选择有重要影响。在以下部分,我们展示呼吸与过敏性疾病(RAD)基金会的两位成员,医学博士托马斯·B·卡萨莱和医学博士迈克尔·S·布莱斯之间的讨论。卡萨莱博士和布莱斯博士就“临床医生在初始诊断和评估时是否应常规确定鼻炎亚型?”这一问题展开辩论。每位专家被随机分配一个立场:卡萨莱博士的观点代表“支持”论点,而布莱斯博士被要求阐述“反对”论点。辩论最后综合了他们的论点和要点,包括对初级保健医生重要的关键信息。

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