迟发性重症肌无力患者 CD8(+) T 细胞中 TCR Vbeta 亚群的扩展：与胸腺瘤患者的新平行关系。
Expanded TCR Vbeta subsets of CD8(+) T-cells in late-onset myasthenia gravis: novel parallels with thymoma patients.
机构信息
Philipps-University, Clinical Neuroimmunology Group, Department of Neurology, Marburg, Germany.
出版信息
J Neuroimmunol. 2009 Nov 30;216(1-2):85-91. doi: 10.1016/j.jneuroim.2009.08.018. Epub 2009 Sep 24.
Little is known about pathogenesis -- and especially about involvement of CD8(+) T-cells -- in late-onset myasthenia gravis (LOMG). Remarkably, outstanding CD8(+) TCRVbeta-subset expansions were found in 64% and 72% of recent onset LOMG or thymoma-associated MG (vs. 16% with early-onset MG (p<0.0002); 21% in older controls (p<0.001)). In LOMG, ~25% of the expanded cells initially showed a naïve CD62L(+hi)/CD45RA(+) recent thymic emigrant (RTE)-like phenotype. These expansions associated significantly with IgG antibodies against cytomegalovirus (p<0.036), IL-12 and/ or IFN-alpha2 (p<0.03). The CD8(+) TCRVbeta expansions were stable over 5years, but RTE markers declined.
关于发病机制（尤其是 CD8(+) T 细胞的参与）在迟发性重症肌无力（LOMG）中的了解甚少。值得注意的是，在最近发病的 LOMG 或胸腺瘤相关重症肌无力（MG）患者中，发现了高达 64%和 72%的显著 CD8(+) TCRVbeta 亚群扩增（而在早发性 MG 患者中为 16%（p<0.0002）；在老年对照组中为 21%（p<0.001））。在 LOMG 中，约 25%的扩增细胞最初表现出幼稚 CD62L(+hi)/CD45RA(+) 近期胸腺迁出细胞（RTE）样表型。这些扩增与针对巨细胞病毒的 IgG 抗体显著相关（p<0.036），与 IL-12 和/或 IFN-alpha2 相关（p<0.03）。CD8(+) TCRVbeta 扩增在 5 年内保持稳定，但 RTE 标志物下降。
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