召唤小泛素样修饰蛋白来对抗炎症。
Summon SUMO to wrestle with inflammation.
作者信息
Liu Bin, Shuai Ke
机构信息
Division of Hematology-Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
出版信息
Mol Cell. 2009 Sep 24;35(6):731-2. doi: 10.1016/j.molcel.2009.09.002.
PMID:19782020
Abstract
In this issue of Molecular Cell, Lee et al. (2009) report that SUMOylation of nuclear receptors LXRalpha and LXRbeta plays a critical role in the transrepression of IFN-gamma-induced STAT1-dependent inflammatory responses in brain astrocytes.
摘要
在本期《分子细胞》杂志中，李等人（2009年）报道，核受体LXRα和LXRβ的SUMO化在脑星形胶质细胞中对干扰素-γ诱导的STAT1依赖性炎症反应的反式抑制中起关键作用。
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