Department of Psychiatry, University of Melbourne and Melbourne Health, Melbourne Neuropsychiatry Centre, Victoria, Australia.
J Affect Disord. 2010 May;122(3):301-5. doi: 10.1016/j.jad.2009.09.003. Epub 2009 Sep 25.
Morphologic changes of cortico-limbic regions have been reported in bipolar disorder, but it remains unclear whether midline brain abnormalities relevant to cortico-limbic connectivity are also present.
We used magnetic resonance imaging to investigate the size of the adhesio interthalamica (AI) and cavum septi pellucidi (CSP), as well as third ventricular volume, in 26 patients with bipolar I disorder and 24 matched controls.
CSP length and prevalence of a large CSP did not differ between the groups, but bipolar patients had significantly shorter AI and larger third ventricles compared to controls.
A comprehensive investigation of medication effects was not possible due to incomplete medication data.
These findings implicate a role for the AI and connected brain regions in the neurobiology of bipolar disorder.
双相情感障碍患者的皮质边缘区域存在形态学变化，但皮质边缘连接相关的中线脑区是否存在异常尚不清楚。
我们使用磁共振成像技术研究了 26 例双相 I 型障碍患者和 24 名匹配对照者的黏连连合（AI）和透明隔腔（CSP）的大小，以及第三脑室容积。
两组间 CSP 长度和大 CSP 的发生率无差异，但与对照组相比，双相患者的 AI 明显较短，第三脑室较大。
由于药物数据不完整，无法全面研究药物的影响。
这些发现提示黏连连合和相关脑区在双相情感障碍的神经生物学中起作用。
