Lindefors N, Ungerstedt U
Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Neurosci Lett. 1990 Jul 31;115(2-3):248-52. doi: 10.1016/0304-3940(90)90463-j.
Tissue levels and in vivo release of glutamate were measured in caudate-putamen of rat brain after a unilateral 6-hydroxydopamine lesion of meso-striatal/meso-cortico-limbic dopamine neurons. The results were compared with glutamate levels from corresponding regions in sham-injected animals. The unilateral dopamine lesion induced a bilateral increase of tissue levels of glutamate (45% ipsilateral and 39% contralateral to the lesion). Extracellular levels of glutamate as measured by microdialysis were also bilaterally increased (107% ipsilateral and 94% contralateral to the lesion). The results indicate that mesencephalic dopamine neurons regulate neuronal glutamate in ipsilateral as well as contralateral caudate-putamen.
在对大鼠中脑-纹状体/中脑-皮质-边缘多巴胺神经元进行单侧6-羟基多巴胺损伤后，测量了大鼠脑尾状核-壳核中的谷氨酸组织水平和体内释放情况。将结果与假注射动物相应区域的谷氨酸水平进行了比较。单侧多巴胺损伤导致谷氨酸组织水平双侧升高（损伤同侧升高45%，对侧升高39%）。通过微透析测量的谷氨酸细胞外水平也双侧升高（损伤同侧升高107%，对侧升高94%）。结果表明，中脑多巴胺神经元调节同侧以及对侧尾状核-壳核中的神经元谷氨酸。
