Department of Obstetrics and Gynecology, Rouen University Hospital, France.
Am J Obstet Gynecol. 2010 Jan;202(1):54.e1-5. doi: 10.1016/j.ajog.2009.08.019. Epub 2009 Sep 26.
We sought to evaluate whether testing for hereditary thrombophilia alone or in combination with second-trimester uterine artery Doppler (UAD) is useful in predicting recurrent complications in patients with previous preeclampsia, placental abruption, or stillbirth.
Between 2001 and 2005, 110 consecutive women were included in the study and received 100 mg of aspirin daily. Adjustment was made for several maternal confounding factors using a logistic regression model.
After multivariable logistic regression analyses, only abnormal UAD assessment was significantly associated with recurrent complications (odds ratio, 11.2; 95% confidence interval, 3.8-32.6) Combining the results of UAD and the presence of laboratory markers of thrombophilia failed to improve the accuracy of UAD to predict recurrent complications.
Hereditary thrombophilia testing is not useful in predicting recurrent complications in subsequent pregnancy.
我们旨在评估单独检测遗传性血栓形成倾向或联合检测中期子宫动脉多普勒（UAD）是否有助于预测既往子痫前期、胎盘早剥或死胎患者的再次并发症。
2001 年至 2005 年间，共纳入 110 例连续患者，每日接受 100mg 阿司匹林治疗。采用逻辑回归模型对多种母体混杂因素进行了调整。
经多变量逻辑回归分析，仅异常 UAD 评估与再次并发症显著相关（比值比，11.2；95%置信区间，3.8-32.6）。联合 UAD 结果和血栓形成倾向的实验室标志物并不能提高 UAD 预测再次并发症的准确性。
遗传性血栓形成倾向检测无助于预测后续妊娠中的再次并发症。
