Departments of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, California 94305-5723, USA.
Biol Psychiatry. 2010 Jan 1;67(1):44-51. doi: 10.1016/j.biopsych.2009.08.008.
Posturography analysis of static balance reveals marked sway and tremor in sober alcoholic men related to anterior vermis volume but can be attenuated by simple visual or tactile cues or alterations in stance. Whether alcoholic women, whose ataxia can persist with prolonged sobriety, exhibit the same physiological signature of balance instability and relation to cerebellar vermian volume as alcoholic men or can benefit from stabilizing factors is unknown.
Groups comprised 15 alcohol-dependent women, alcohol-free (median 3 months) and 29 control women. Groups were matched in age, demographic features, and finger movement speed and underwent balance platform testing and magnetic resonance imaging scanning.
Alcoholic women exhibited excessive sway path length (.6 SD), more dramatic in the anterior-posterior than medial-lateral direction. Truncal tremor, measured as peak sway velocity frequency, was disproportionately great in the 5 Hz to 7 Hz band of alcoholics. Control subjects and alcoholics exhibited sway and tremor reduction with visual, tactile, or stance-stabilizing conditions, which aided both groups equally well; thus, alcoholic women never achieved normal stability. Smaller anterior vermian volumes selectively correlated with longer sway path and higher 5 Hz to 7 Hz peak sway velocity.
Sway and tremor abnormalities and the selective relations between greater sway and 5 Hz to 7 Hz tremor and smaller volumes of the anterior vermis had not heretofore been described in abstinent alcoholic women. Reduction in sway and tremor with stabilizing factors indicate that adaptive mechanisms involving sensorimotor integration can be invoked to compensate for vermian-related dysfunction.
静态平衡的姿势描记法分析显示，清醒的酒精男性出现明显的晃动和震颤，与前蚓部体积有关，但可以通过简单的视觉或触觉提示或姿势改变来减轻。然而，长期戒酒仍可能存在共济失调的酒精女性，是否表现出与酒精男性相同的平衡不稳定生理特征，以及与小脑蚓部体积的关系，或者是否可以受益于稳定因素，目前尚不清楚。
研究组包括 15 名酒精依赖女性，酒精戒断（中位数 3 个月）和 29 名对照组女性。两组在年龄、人口统计学特征、手指运动速度方面相匹配，并进行平衡平台测试和磁共振成像扫描。
酒精女性表现出过度的晃动路径长度（0.6 个标准差），在前-后方向比在中-侧方向更为明显。躯干震颤，以峰值晃动速度频率测量，在酒精组的 5Hz 至 7Hz 频段中不成比例地大。对照组和酒精组在视觉、触觉或稳定姿势条件下表现出晃动和震颤减少，这两种方法对两组都同样有效；因此，酒精女性从未达到正常的稳定性。较小的前蚓部体积与较长的晃动路径和较高的 5Hz 至 7Hz 峰值晃动速度选择性相关。
摆动和震颤异常，以及较大的摆动和 5Hz 至 7Hz 震颤与前蚓部体积之间的选择性关系，在戒酒的酒精女性中以前尚未描述过。稳定因素减少晃动和震颤表明，涉及感觉运动整合的适应性机制可以被调用以补偿蚓部相关的功能障碍。
