莫达非尼对可卡因滥用者不起强化作用。
Modafinil does not serve as a reinforcer in cocaine abusers.
机构信息
College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, United States.
出版信息
Drug Alcohol Depend. 2010 Jan 15;106(2-3):233-6. doi: 10.1016/j.drugalcdep.2009.09.002. Epub 2009 Sep 23.
Abstract
The purpose of this double-blind, randomized, outpatient study was to evaluate the reinforcing and subjective effects of modafinil (200, 400, or 600 mg) in cocaine abusers. Twelve participants (2 female, 10 male) completed this study, consisting of 3 blocks of 7 sessions; each block tested a difference dose of modafinil. During the first 2 sessions of each block, participants "sampled" 1 of the doses of modafinil, and placebo. These doses of modafinil and placebo were available for the subsequent five choice sessions of the block. In each choice session, participants had an opportunity to administer active or placebo capsules. Modafinil administration did not differ from placebo administration, and subjective-effects ratings were not systematically altered as a function of modafinil dose. Results suggest that modafinil does not have abuse liability in cocaine abusers.
摘要
本双盲、随机、门诊研究的目的是评估莫达非尼（200、400 或 600 毫克）在可卡因滥用者中的强化和主观效应。12 名参与者（2 名女性，10 名男性）完成了这项研究，包括 3 个 7 次疗程的疗程；每个疗程测试莫达非尼的不同剂量。在每个疗程的前 2 个疗程中，参与者“采样”了莫达非尼和安慰剂的 1 个剂量。这些莫达非尼和安慰剂的剂量可用于该疗程的随后五个选择疗程。在每个选择疗程中，参与者有机会服用活性或安慰剂胶囊。莫达非尼的给药与安慰剂的给药没有区别，并且主观效应评分也没有随着莫达非尼剂量的变化而系统地改变。结果表明，莫达非尼在可卡因滥用者中没有滥用倾向。
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