A combined, rational approach towards inhibition of the MEK-ERK and mTOR pathways in pancreatic ductal adenocarcinoma: promise or deja vu?
作者信息
Rhim Andrew D
机构信息
Gastroenterology Division, Department of Medicine and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
出版信息
Cancer Biol Ther. 2009 Oct;8(20):1902-3. doi: 10.4161/cbt.8.20.9810. Epub 2009 Oct 14.
Abstract
摘要
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A combined, rational approach towards inhibition of the MEK-ERK and mTOR pathways in pancreatic ductal adenocarcinoma: promise or deja vu?一种联合、合理的抑制胰腺导管腺癌中MEK-ERK和mTOR信号通路的方法：是希望还是似曾相识？
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本文引用的文献
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Effects of combined inhibition of MEK and mTOR on downstream signaling and tumor growth in pancreatic cancer xenograft models.MEK 和 mTOR 联合抑制对胰腺癌异种移植模型下游信号和肿瘤生长的影响。
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2
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.在胰腺癌小鼠模型中，抑制刺猬信号通路可增强化疗药物的递送。
Science. 2009 Jun 12;324(5933):1457-61. doi: 10.1126/science.1171362. Epub 2009 May 21.
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KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas.KRAS基因第12密码子突变在胰腺腺癌中非常常见。
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Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes.
Cell. 1988 May 20;53(4):549-54. doi: 10.1016/0092-8674(88)90571-5.
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In vitro and in vivo radiosensitivity of human tumour cells obtained from a pancreatic carcinoma xenograft.从胰腺癌异种移植瘤中获取的人肿瘤细胞的体外和体内放射敏感性
Nature. 1976 Oct 28;263(5580):771-2. doi: 10.1038/263771a0.
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