哌啶酸的肉碱共轭物：双重前药的一个新实例。
Carnitine conjugate of nipecotic acid: a new example of dual prodrug.
作者信息
Napolitano Carmela, Scaglianti Martina, Scalambra Emanuela, Manfredini Stefano, Ferraro Luca, Beggiato Sarah, Vertuani Silvia
机构信息
Department of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy.
出版信息
Molecules. 2009 Aug 31;14(9):3268-74. doi: 10.3390/molecules14093268.
Abstract
As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.
摘要
作为通过营养物偶联物改善难递送药物进入大脑的一个新例子，将L-肉碱与哌啶酸偶联，并评估了这种新实体拮抗戊四氮诱导惊厥的能力。
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