Synthesis and cytotoxicity of novel hexahydrothienocycloheptapyridazinone derivatives.
作者信息
Pau Amedeo, Murineddu Gabriele, Asproni Battistina, Murruzzu Caterina, Grella Giuseppe E, Pinna Gérard A, Curzu Maria M, Marchesi Irene, Bagella Luigi
机构信息
Dipartimento Farmaco Chimico Tossicologico,Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy.
出版信息
Molecules. 2009 Sep 9;14(9):3494-508. doi: 10.3390/molecules14093494.
Abstract
Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothienocycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.
摘要
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