Boukharsa Youness, Karrouchi Khalid, Attjioui Houda, Ansar M'Hammed
Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
Higher Institute of Nursing Professions and Technical Health (ISPITS), Casablanca, Morocco.
Mini Rev Med Chem. 2025;25(1):3-26. doi: 10.2174/0113895575287746240528072330.
Pyridazinones are classical molecules that occupy an important place in heterocyclic chemistry, and since their discovery, they have been widely developed. The introduction of new functional groups into pyridazinone structures has enabled the synthesis of a large diversity of compounds. The pharmacological and agrochemical importance of pyridazinone derivatives has aroused the interest of chemists and directed their research toward the synthesis of new compounds with the aim of improving their biological effectiveness. In this review, we have compiled and discussed the different synthetic routes, reactivity, and pharmacological and agrochemical applications of the pyridazinone ring.
哒嗪酮是在杂环化学中占据重要地位的经典分子，自其被发现以来，已得到广泛开发。在哒嗪酮结构中引入新的官能团使得能够合成种类繁多的化合物。哒嗪酮衍生物在药理学和农业化学方面的重要性引起了化学家们的兴趣，并引导他们开展研究以合成新化合物，旨在提高其生物活性。在本综述中，我们汇编并讨论了哒嗪酮环的不同合成路线、反应性以及药理学和农业化学应用。
