揭示神经性疼痛中的紧张性不适状态。
Unmasking the tonic-aversive state in neuropathic pain.
机构信息
Department of Pharmacology, University of Arizona, Tucson, Arizona, USA.
出版信息
Nat Neurosci. 2009 Nov;12(11):1364-6. doi: 10.1038/nn.2407. Epub 2009 Sep 27.
Abstract
Tonic pain has been difficult to demonstrate in animals. Because relief of pain is rewarding, analgesic agents that are not rewarding in the absence of pain should become rewarding only when there is ongoing pain. We used conditioned place preference to concomitantly determine the presence of tonic pain in rats and the efficacy of agents that relieve it. This provides a new approach for investigating tonic pain in animals and for evaluating the analgesic effects of drugs.
摘要
躯体痛在动物中很难表现出来。因为缓解疼痛是有奖励的，所以在没有疼痛的情况下没有奖励作用的镇痛剂，只有在持续疼痛时才会具有奖励作用。我们使用条件性位置偏爱来同时确定大鼠躯体痛的存在和缓解它的药物的疗效。这为研究动物的躯体痛和评估药物的镇痛效果提供了一种新方法。
相似文献
1
Unmasking the tonic-aversive state in neuropathic pain.
Nat Neurosci. 2009 Nov;12(11):1364-6. doi: 10.1038/nn.2407. Epub 2009 Sep 27.
2
Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy.
Pain. 2011 Jul;152(7):1641-1648. doi: 10.1016/j.pain.2011.03.002. Epub 2011 Apr 6.
3
Antinociceptive effects of the marine snail peptides conantokin-G and conotoxin MVIIA alone and in combination in rat models of pain.
Neuropharmacology. 2009 Feb;56(2):556-63. doi: 10.1016/j.neuropharm.2008.10.008. Epub 2008 Oct 26.
4
Pregabalin induces conditioned place preference in the rat during the early, but not late, stage of neuropathic pain.
Neurosci Lett. 2018 Mar 6;668:133-137. doi: 10.1016/j.neulet.2018.01.029. Epub 2018 Jan 31.
5
Conditioned place preference reveals tonic pain in an animal model of central pain.
J Pain. 2011 Aug;12(8):868-74. doi: 10.1016/j.jpain.2011.01.010. Epub 2011 Apr 23.
6
Changes in morphine reward in a model of neuropathic pain.
Behav Pharmacol. 2013 Jun;24(3):207-13. doi: 10.1097/FBP.0b013e3283618ac8.
7
Spinal actions of ω-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model.
Br J Pharmacol. 2013 Sep;170(2):245-54. doi: 10.1111/bph.12251.
8
Effect of Ceftiofur on Hyperalgesia and Allodynia in a Rat Neuropathic Pain Model: The Role of Immune Processes.
Neuroimmunomodulation. 2017;24(1):21-28. doi: 10.1159/000475757. Epub 2017 Jun 15.
9
Dorsal Root Ganglionic Field Stimulation Relieves Spontaneous and Induced Neuropathic Pain in Rats.
J Pain. 2016 Dec;17(12):1349-1358. doi: 10.1016/j.jpain.2016.09.004. Epub 2016 Sep 26.
10
Nitrous oxide persistently alleviates pain hypersensitivity in neuropathic rats: A dose-dependent effect.
Pain Res Manag. 2015 Nov-Dec;20(6):309-15. doi: 10.1155/2015/809059. Epub 2015 Sep 15.
引用本文的文献
1
Descending projection neurons in the primary sensorimotor cortex regulate neuropathic pain and locomotion in mice.
Nat Commun. 2025 Jul 3;16(1):5918. doi: 10.1038/s41467-025-61164-8.
2
CXCL13/CXCR5: a new target for pain treatment - a review article.
Int J Surg. 2025 Jun 20. doi: 10.1097/JS9.0000000000002764.
3
Mechanism and modulation of spontaneous pain: from neural circuits to drug development.
Mol Biol Rep. 2025 Jun 4;52(1):542. doi: 10.1007/s11033-025-10659-0.
4
Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain.
Cell. 2025 Aug 7;188(16):4332-4349.e21. doi: 10.1016/j.cell.2025.04.038. Epub 2025 May 19.
5
Decoding the mechanism of proanthocyanidins in central analgesia: redox regulation and KCNK3 blockade.
Exp Mol Med. 2025 Mar;57(3):567-583. doi: 10.1038/s12276-025-01412-5. Epub 2025 Mar 3.
6
Editorial: Preclinical animal models and measures of pain: improving predictive validity for analgesic drug development - volume II.
Front Pain Res (Lausanne). 2025 Jan 7;5:1523938. doi: 10.3389/fpain.2024.1523938. eCollection 2024.
7
Spinal astrocyte-derived interleukin-17A promotes pain hypersensitivity in bone cancer mice.
Acta Pharm Sin B. 2024 Dec;14(12):5249-5266. doi: 10.1016/j.apsb.2024.09.016. Epub 2024 Sep 21.
8
Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors.
Nat Neurosci. 2025 Feb;28(2):336-345. doi: 10.1038/s41593-024-01807-z. Epub 2025 Jan 2.
9
Site-specific drug release of monomethyl fumarate to treat oxidative stress disorders.
Nat Biotechnol. 2024 Nov 4. doi: 10.1038/s41587-024-02460-4.
10
Closed-loop neural interfaces for pain: Where do we stand?
Cell Rep Med. 2024 Oct 15;5(10):101662. doi: 10.1016/j.xcrm.2024.101662.
本文引用的文献
1
Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards.
Pain. 2008 Oct 15;139(2):243-247. doi: 10.1016/j.pain.2008.08.017. Epub 2008 Sep 23.
2
Direct evidence for the involvement of endogenous beta-endorphin in the suppression of the morphine-induced rewarding effect under a neuropathic pain-like state.
Neurosci Lett. 2008 Apr 25;435(3):257-62. doi: 10.1016/j.neulet.2008.02.059. Epub 2008 Mar 4.
3
Clinical and pre-clinical pain assessment: are we measuring the same thing?
Pain. 2008 Mar;135(1-2):7-10. doi: 10.1016/j.pain.2007.12.008. Epub 2008 Jan 22.
4
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics.
Anesthesiology. 2007 Feb;106(2):312-22. doi: 10.1097/00000542-200702000-00020.
5
Mechanisms of neuropathic pain.
Neuron. 2006 Oct 5;52(1):77-92. doi: 10.1016/j.neuron.2006.09.021.
6
Mechanisms of neuropathic pain and their implications for the design of clinical trials.
Neurology. 2005 Dec 29;65(12 Suppl 4):S66-73. doi: 10.1212/wnl.65.12_suppl_4.s66.
7
Neuropathic pain symptoms relative to overall pain rating.
J Pain. 2004 Nov;5(9):491-7. doi: 10.1016/j.jpain.2004.09.001.
8
State-dependent opioid control of pain.
Nat Rev Neurosci. 2004 Jul;5(7):565-75. doi: 10.1038/nrn1431.
9
Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli.
Science. 2004 Mar 26;303(5666):2040-2. doi: 10.1126/science.1093360.
10
Intrathecal, but not intravenous adenosine reduces allodynia in patients with neuropathic pain.
Pain. 2003 Sep;105(1-2):65-70. doi: 10.1016/s0304-3959(03)00158-1.
Zotero 插件