揭示神经性疼痛中的紧张性不适状态。
Unmasking the tonic-aversive state in neuropathic pain.
机构信息
Department of Pharmacology, University of Arizona, Tucson, Arizona, USA.
出版信息
Nat Neurosci. 2009 Nov;12(11):1364-6. doi: 10.1038/nn.2407. Epub 2009 Sep 27.
Abstract
Tonic pain has been difficult to demonstrate in animals. Because relief of pain is rewarding, analgesic agents that are not rewarding in the absence of pain should become rewarding only when there is ongoing pain. We used conditioned place preference to concomitantly determine the presence of tonic pain in rats and the efficacy of agents that relieve it. This provides a new approach for investigating tonic pain in animals and for evaluating the analgesic effects of drugs.
摘要
躯体痛在动物中很难表现出来。因为缓解疼痛是有奖励的，所以在没有疼痛的情况下没有奖励作用的镇痛剂，只有在持续疼痛时才会具有奖励作用。我们使用条件性位置偏爱来同时确定大鼠躯体痛的存在和缓解它的药物的疗效。这为研究动物的躯体痛和评估药物的镇痛效果提供了一种新方法。
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