降钙素基因相关肽（CGRP）受体拮抗剂：抗偏头痛药物的新前沿。
CGRP receptor antagonists: A new frontier of anti-migraine medications.
作者信息
de Prado Blanca Marquez, Russo Andrew F
机构信息
Department of Physiology and Biophysics, 51 Newton Road, University of Iowa, Iowa City, IA 52242, USA.
出版信息
Drug Discov Today Ther Strateg. 2006 Winter;3(4):593-597. doi: 10.1016/j.ddstr.2006.11.003.
Abstract
Migraine is a chronic pain condition that affects 12% of the population. Currently, the most effective treatments are the triptans, but they are limited in their efficacy and have potentially deleterious cardiovascular complications. Based on basic science studies over the past decade, a new generation of anti-migraine drugs is now being developed. At the forefront of these studies is a new calcitonin gene-related peptide (CGRP) receptor antagonist that is as effective as triptans in the acute treatment of migraines, without the cardiovascular effects. This review will address the likely mechanisms and therapeutic potential of CGRP receptor antagonists.
摘要
偏头痛是一种慢性疼痛病症，影响着12%的人口。目前，最有效的治疗药物是曲坦类药物，但它们的疗效有限，且有潜在的有害心血管并发症。基于过去十年的基础科学研究，新一代抗偏头痛药物正在研发中。这些研究的前沿是一种新的降钙素基因相关肽（CGRP）受体拮抗剂，它在偏头痛的急性治疗中与曲坦类药物一样有效，且没有心血管方面的影响。这篇综述将探讨CGRP受体拮抗剂可能的作用机制和治疗潜力。
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本文引用的文献
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J Neurosci. 2006 Jun 7;26(23):6163-71. doi: 10.1523/JNEUROSCI.0647-06.2006.
2
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Bioorg Med Chem Lett. 2006 May 15;16(10):2595-8. doi: 10.1016/j.bmcl.2006.02.051. Epub 2006 Mar 9.
3
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Ann Neurol. 2005 Oct;58(4):561-8. doi: 10.1002/ana.20605.
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J Neurosci. 2005 Jun 22;25(25):5877-83. doi: 10.1523/JNEUROSCI.0869-05.2005.
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