Khouri Vivian Youssef, Stracieri Ana Beatriz Pereira Lima, Rodrigues Maria Carolina, Moraes Daniela Aparecida de, Pieroni Fabiano, Simões Belinda Pinto, Voltarelli Júlio César
University Hospital, University of São Paulo, Ribeirão Preto, SP, Brazil.
Braz Dent J. 2009;20(3):215-20. doi: 10.1590/s0103-64402009000300008.
Oral mucositis (OM) affects patients who are submitted to hematopoietic stem cell transplantation (HSCT) due to high doses of chemotherapy and/or radiotherapy. The purpose of this investigation was to perform a comparative study of the frequency and evolution of OM among patients subjected to therapeutic laser and to the conventional therapy (use of mouthwash called 'Mucositis Formula'). The patients were subjected to a myeloablative conditioning regimen before the allogeneic HSCT. Twenty-two patients were selected and divided into 2 groups: group I was irradiated with InGaAlP laser (660 nm) and GaAlAs laser (780 nm), 25 mW potency, 6.3J/cm(2) dose, in 10-s irradiation time, followed to conventional treatment; group II was subjected only to the conventional treatment. Both World Health Organization (WHO) scale and the Oral Mucositis Assessment Scale (OMAS) were used to evaluate the results. Data were analyzed by the non-parametric Wilcoxon test, with p<0.05 considered as statistically significant. Group I presented a lower frequency of OM (p=0.02) and lower mean scores, according to WHO and OMAS scales (p<0.01 and p=0.01, respectively). In conclusion, laser reduced the frequency and severity of OM, suggesting that therapeutic laser can be used both as a new form of prevention and treatment of OM.
口腔黏膜炎（OM）会影响因高剂量化疗和/或放疗而接受造血干细胞移植（HSCT）的患者。本研究的目的是对接受治疗性激光治疗的患者与接受传统治疗（使用名为“黏膜炎配方”的漱口水）的患者中OM的发生率及病程进行比较研究。患者在异基因HSCT前接受了清髓性预处理方案。选取22例患者并分为两组：第一组用InGaAlP激光（660nm）和GaAlAs激光（780nm）照射，功率25mW，剂量6.3J/cm²，照射时间10秒，随后进行传统治疗；第二组仅接受传统治疗。采用世界卫生组织（WHO）量表和口腔黏膜炎评估量表（OMAS）来评估结果。数据通过非参数Wilcoxon检验进行分析，p<0.05被认为具有统计学意义。根据WHO和OMAS量表，第一组的OM发生率较低（p=0.02）且平均得分较低（分别为p<0.01和p=0.01）。总之，激光降低了OM的发生率和严重程度，表明治疗性激光可作为预防和治疗OM的一种新形式。
