Shi C Z, Li X M, Liu Y, Zhang J T
Institute of Materia Me lica, Chinese Academy of Medical Sciences, Beijing.
Yao Xue Xue Bao. 1990;25(3):223-6.
Isolated mouse tail artery strip was used for the study of alpha 1-, alpha 2-adrenoceptor agonists and antagonists. NA (alpha 1 and alpha 2 agonist) was shown to have greater activity in contracting tail artery. Phenylephrine (alpha 1 agonist) and clonidine (alpha 2 agonist) exhibited the same contractile action but much weaker than NA. Prazosin (alpha 1 antagonist) and yohimbine (alpha 2 antagonist) greatly diminished the contraction induced by phenylephrine and clonidine. These results indicate that mouse tail artery is rich in postsynaptic alpha 1- and alpha 2-adrenoceptor. In addition, mouse tail artery preparation was shown to be a useful tool for screening calcium agonists and antagonists. This model has advantages of being simple and easy to prepare, short equilibrium time and more economic in comparison with the helical strips of isolated rat tail artery.
分离的小鼠尾动脉条用于研究α1、α2肾上腺素能受体激动剂和拮抗剂。去甲肾上腺素（α1和α2激动剂）在收缩尾动脉方面表现出更强的活性。去氧肾上腺素（α1激动剂）和可乐定（α2激动剂）表现出相同的收缩作用，但比去甲肾上腺素弱得多。哌唑嗪（α1拮抗剂）和育亨宾（α2拮抗剂）极大地减弱了去氧肾上腺素和可乐定诱导的收缩。这些结果表明，小鼠尾动脉富含突触后α1和α2肾上腺素能受体。此外，小鼠尾动脉标本被证明是筛选钙激动剂和拮抗剂的有用工具。与分离的大鼠尾动脉螺旋条相比，该模型具有制备简单、平衡时间短和更经济的优点。
