Higgitt A, Fonagy P, Toone B, Shine P
St Charles Hospital, London, United Kingdom.
Acta Psychiatr Scand. 1990 Aug;82(2):165-8. doi: 10.1111/j.1600-0447.1990.tb01375.x.
In an attempt to establish whether prolonged withdrawal symptoms after stopping intake of benzodiazepines is caused by return of anxiety, hysteria, abnormal illness behaviour or the dependence process itself producing perhaps a prolonged neurotransmitter imbalance, a group of such patients suffering prolonged withdrawal symptoms (PWS) was compared on a range of psychophysiological measures with matched groups of anxious and conversion hysteria patients and normal controls. It was found that the psychophysiological markers of anxiety were not marked in the PWS group; nor were the averaged evoked response abnormalities found to be associated with cases of hysterical conversion in evidence. The PWS group were hard to distinguish from normal controls on the basis of psychophysiological measures and thus it was felt to be unlikely to be an affective disturbance. It was concluded that PWS is likely to be a genuine iatrogenic condition, a complication of long-term benzodiazepine treatment.
为了确定停用苯二氮䓬类药物后出现的长期戒断症状是由焦虑、癔症、异常疾病行为的复发引起的，还是由依赖过程本身导致的可能长期神经递质失衡引起的，将一组患有长期戒断症状（PWS）的患者与焦虑症患者、转换性癔症患者匹配组以及正常对照组在一系列心理生理指标上进行了比较。结果发现，PWS组中焦虑的心理生理指标并不明显；也未发现平均诱发电位异常与癔症性转换病例有关。基于心理生理指标，PWS组很难与正常对照组区分开来，因此认为不太可能是情感障碍。得出的结论是，PWS可能是一种真正的医源性疾病，是长期苯二氮䓬类药物治疗的并发症。
