Fehr A, Stenman G, Bullerdiek J, Löning T
Zentrum für Humangenetik, Universität Bremen, Bremen.
Pathologe. 2009 Nov;30(6):466-71. doi: 10.1007/s00292-009-1206-4.
The molecular genetic background of salivary gland neoplasms has not been characterized in detail to date. However, interesting target genes which could be used as prognostic and diagnostic molecular biomarkers have already been identified, e.g. CRTC1-MAML2 in mucoepidermoid carcinoma, or PLAG1 and HMGA2 in pleomorphic adenoma. In particular, CRTC1-MAML2 has shown strong diagnostic and prognostic potential in recent years. One of the major advantages of molecular tumor markers is that valid results are obtained on minute cell and/or tissue samples. Due to high-throughput techniques like comparative genome hybridization (CGH), micro- or gene profiling array detection of new marker genes can be expected in the future. This is also true for the most frequent malignant salivary gland tumors after the mucoepidermoid carcinoma, i.e. adenoid cystic carcinomas and acinic cell carcinomas.
迄今为止，涎腺肿瘤的分子遗传背景尚未得到详细描述。然而，已经确定了一些有趣的靶基因，它们可作为预后和诊断的分子生物标志物，例如黏液表皮样癌中的CRTC1-MAML2，或多形性腺瘤中的PLAG1和HMGA2。特别是，CRTC1-MAML2近年来已显示出强大的诊断和预后潜力。分子肿瘤标志物的主要优势之一是能够从小细胞和/或组织样本中获得有效的结果。由于诸如比较基因组杂交（CGH）等高通量技术，未来有望检测到新的标志物基因的微阵列或基因谱。对于黏液表皮样癌之后最常见的恶性涎腺肿瘤，即腺样囊性癌和腺泡细胞癌，情况也是如此。
