Laboratorio di Fisiologia generale, Dipartimento di Biologia cellulare e dello Sviluppo, Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy.
J Physiol Sci. 2010 Jan;60(1):75-9. doi: 10.1007/s12576-009-0060-8. Epub 2009 Sep 26.
Duchenne muscular dystrophy (DMD), which results from deficiency in dystrophin, a sarcolemma protein of skeletal, cardiac and smooth muscle, is characterized by progressive striated muscle degeneration, but various gastrointestinal clinical manifestations have been observed. The aim was to evaluate the possible impact of the dystrophin loss on the gastrointestinal propulsion in mdx mice (animal model for DMD). The gastric emptying of a carboxymethyl cellulose/phenol red dye non-nutrient meal was not significantly different at 20 min from gavaging between wild-type and mdx mice. The intestinal transit and the fecal output were significantly decreased in mdx versus normal animals, although the length of the intestine was similar in both animals. The present results provide evidence for motor intestinal alterations in mdx mice in in vivo conditions.
杜氏肌营养不良症（DMD）是由于肌营养不良蛋白的缺乏引起的，肌营养不良蛋白是骨骼肌、心肌和平滑肌的肌膜蛋白，其特征是进行性横纹肌退化，但也观察到各种胃肠道临床表现。本研究旨在评估肌营养不良蛋白缺失对 mdx 小鼠（DMD 的动物模型）胃肠道推进的可能影响。胃排空羧甲基纤维素/酚红染料非营养餐在 20 分钟时与野生型和 mdx 小鼠的灌胃相比没有显著差异。尽管两种动物的肠道长度相似，但 mdx 与正常动物相比，肠道转运和粪便排出明显减少。本研究结果为 mdx 小鼠在体内条件下存在运动性肠道改变提供了证据。
