Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, 030006, Taiyuan, People's Republic of China.
Biotechnol Lett. 2010 Jan;32(1):11-8. doi: 10.1007/s10529-009-0132-0. Epub 2009 Sep 27.
Malignant gliomas are typically characterized by rapid cell proliferation and a marked propensity to invade and damage surrounding tissues. They are the main brain tumors notoriously resistant to currently available therapies, since they fail to undergo apoptosis upon anticancer treatments. With recent advances in neuroscience and improved understanding of the molecular mechanisms of invasive migration, gene therapy provides a new strategy for treating glioma cancer. Brain tumor gene therapy using viral vectors and stem cells has shown promise in animal model and human patient studies. Here, we review recent studies on engineering adenoviral vectors that can be used as therapy for brain tumors. The new findings presented in this study are essential for the further exploration of this cancer and they represent an approach for developing a newer and more effective therapeutic approach in the clinical treatment of human glioma cancer.
恶性脑胶质瘤的特征通常为细胞快速增殖，以及侵袭和破坏周围组织的明显倾向。它们是目前可用疗法难以治疗的主要脑肿瘤，因为它们在抗癌治疗后无法发生细胞凋亡。随着神经科学的最新进展和对侵袭性迁移的分子机制的深入了解，基因治疗为治疗脑胶质瘤提供了一种新策略。利用病毒载体和干细胞的脑肿瘤基因治疗在动物模型和人类患者研究中显示出了前景。在这里，我们综述了近年来用于脑肿瘤治疗的腺病毒载体工程的研究进展。本研究中提出的新发现对于进一步探索这种癌症至关重要，并且代表了在人类脑胶质瘤的临床治疗中开发更新型和更有效的治疗方法的一种途径。
