Department of Obstetrics and Gynecology, University of South Florida, Tampa, Florida, USA.
Am J Perinatol. 2010 Mar;27(3):235-40. doi: 10.1055/s-0029-1239490. Epub 2009 Sep 26.
We sought to determine if there is a relationship between prepregnancy underweight status and placental abruption. We utilized the Missouri maternally linked cohort data files covering the period 1989 through 1997. We estimated the association between prepregnancy underweight subtypes and placental abruption using adjusted odds ratios. Subanalyses were performed to determine whether the amount of weight gained during pregnancy could modify the association. A total of 439,235 singleton pregnancies with 3696 abruptions were analyzed. Underweight mothers had a 40% greater likelihood for placental abruption (odds ratio 1.4; 95% confidence interval 1.3 to 1.5). The risk increased with ascending severity of underweight status ( P for trend <0.01). There was a trend toward decreased risk for placental abruption among underweight women with adequate weight gain in pregnancy. Prepregnancy maternal underweight status is associated with placental abruption. This risk may be reduced with adequate weight gain during pregnancy.
我们试图确定孕前体重不足与胎盘早剥之间是否存在关系。我们利用了密苏里州的母婴关联队列数据文件，涵盖了 1989 年至 1997 年期间的数据。我们使用调整后的优势比来估计孕前体重不足亚型与胎盘早剥之间的关联。进行了亚分析以确定怀孕期间体重增加的量是否可以改变这种关联。总共分析了 439235 例单胎妊娠和 3696 例胎盘早剥。体重不足的母亲发生胎盘早剥的可能性增加了 40%（优势比 1.4；95%置信区间 1.3 至 1.5）。随着体重不足严重程度的增加，风险也增加（趋势 P<0.01）。在怀孕期间体重增加充足的体重不足妇女中，胎盘早剥的风险呈下降趋势。孕前产妇体重不足与胎盘早剥有关。这种风险可能会随着怀孕期间体重的增加而降低。
