Institute of Biopharmaceutical Science, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Pharmacoepidemiol Drug Saf. 2010 Jan;19(1):51-8. doi: 10.1002/pds.1858.
Incorrect dosage was the most common type of medication errors in neonate patients. Different dosing recommendations from common reference sources may have contributed to the errors. This study assesses the compliance rate with the common reference sources in antibiotic dosage prescribed for preterm infants in a neonatal intensive care unit (NICU).
A retrospective study using chart review was conducted at a tertiary care medical center with university affiliation in Taiwan. Study subjects were preterm neonates admitted to the NICU of the medical center between 2000 and 2002 and prescribed at least one antibiotic during the stay. Recommendations from three commonly used reference sources (Pediatric Dosage Handbook, Neonatal Drug Formulary, and Neofax) were employed to evaluate the dosage compliance of the antibiotic prescriptions.
A total of 433 preterm infants and 3459 prescriptions were included. Depending on the reference source used, the percentages of antibiotic prescriptions where both the dose and the interval were compliant with recommendations ranged from 36.88 to 87.54%.
A significant proportion of antibiotics prescribed for preterm neonates in this medical center did not comply with the recommended dosage from common reference sources. Future studies should investigate the clinical impacts of the dosing deviation.
用药错误中最常见的是新生儿用药剂量错误。不同的常用参考源可能提供了不同的剂量建议，从而导致了这些错误。本研究评估了在新生儿重症监护病房（NICU）中，常用参考源在为早产儿开抗生素剂量方面的遵循率。
这是一项在台湾地区一所附属医院的三级医疗中心进行的回顾性研究。研究对象为 2000 年至 2002 年间入住该医疗中心 NICU 的早产儿，且在住院期间至少使用了一种抗生素。使用三种常用参考源（《儿科剂量手册》、《新生儿药物配方》和《Neofax》）的建议来评估抗生素处方的剂量遵循率。
共纳入 433 例早产儿和 3459 张处方。根据所使用的参考源，剂量和间隔均符合建议的抗生素处方比例从 36.88%到 87.54%不等。
该医疗中心为早产儿开的抗生素处方中，相当一部分不符合常用参考源的推荐剂量。未来的研究应调查剂量偏差对临床的影响。
