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用于癌症治疗的小干扰RNA和微小RNA

siRNA and miRNA for the treatment of cancer.

作者信息

Jankovic R, Radulovic S, Brankovic-Magic M

机构信息

Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.

出版信息

J BUON. 2009 Sep;14 Suppl 1:S43-9.

Abstract

In the process of RNA interference (RNAi), small RNAs pair with complementary messenger RNAs preventing their expression. The discovery of RNAi has revolutionized our understanding of gene regulation. Since cancer is a disease of altered genes, RNAi may have tremendous potential as a therapeutic strategy by downregulating altered genes. Just one decade after its discovery, this process is already being used in clinical trials and new technical achievements in delivering small RNAs to the cells are constantly improving the efficiency of this specific cancer treatment.

摘要

在RNA干扰(RNAi)过程中,小RNA与互补信使RNA配对,阻止其表达。RNAi的发现彻底改变了我们对基因调控的理解。由于癌症是一种基因改变的疾病,RNAi作为一种治疗策略,通过下调改变的基因可能具有巨大潜力。在其发现仅仅十年后,这个过程已经被用于临床试验,并且在将小RNA递送至细胞方面的新技术成果不断提高这种特定癌症治疗的效率。

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