采用双能 X 射线吸收法（DXA）对囊性纤维化年轻患者进行临床和营养评估中的骨和身体成分分析：一项横断面研究。
Bone and body composition analyzed by Dual-energy X-ray Absorptiometry (DXA) in clinical and nutritional evaluation of young patients with Cystic Fibrosis: a cross-sectional study.
机构信息
Unit of Cystic Fibrosis, Department of Pediatric Medicine - Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
出版信息
BMC Pediatr. 2009 Sep 28;9:61. doi: 10.1186/1471-2431-9-61.
BACKGROUND
the improved general therapy has led to reduced morbidity and mortality from Cystic Fibrosis (CF), and bone status may have a potentially greater clinical impact.We investigated the correlation between the severity of the clinical condition, bone status and body composition parameters, in a group of children and young adults with CF.
METHODS
we measured lumbar spine bone density and total body composition by dual energy x-ray absorptiometry (DXA) in 82 consecutive CF patients (42 males; median age: 13 years - range: 5-30). Eighty-two healthy subjects, matched for age, gender, height and pubertal stage were recruited as a control group.
RESULTS
37 patients (45.1%) had a normal bone mineral density (BMD). A BMD reduction were observed in 45 (54.8%) patients. Lumbar spine Z score was positively related to Body Mass Index (BMI) and a higher Shwachman-Kulczycki score, and negatively related to Crispin-Norman score. A positive and significant correlation was also observed between lumbar spine Z score and total body composition.
CONCLUSION
a significant BMD reduction can be present early in CF children and adolescents. A careful follow up of bone status is required starting in childhood.
背景
改良的常规疗法降低了囊性纤维化（CF）的发病率和死亡率，而骨骼状况可能具有更大的临床影响。我们研究了一组 CF 患儿和青少年的临床病情严重程度、骨骼状况和身体成分参数之间的相关性。
方法
我们通过双能 X 射线吸收法（DXA）对 82 例连续 CF 患者（42 名男性；中位年龄：13 岁-范围：5-30）的腰椎骨密度和全身成分进行了测量。招募了 82 名年龄、性别、身高和青春期阶段相匹配的健康受试者作为对照组。
结果
37 例（45.1%）患者的骨矿物质密度（BMD）正常。45 例（54.8%）患者存在 BMD 降低。腰椎 Z 评分与体重指数（BMI）和较高的 Shwachman-Kulczycki 评分呈正相关，与 Crispin-Norman 评分呈负相关。腰椎 Z 评分与全身成分之间也存在正相关。
结论
CF 儿童和青少年中可能会出现明显的 BMD 降低。从儿童期开始，需要对骨骼状况进行仔细的随访。
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