Tuinema Rinske M, Uijlings Ruben, Dijkman Marieke A, van den Broek Marcel P H, de Lange Dylan W
Afd. Spoedeisende Hulp, Universitair Medisch Centrum Utrecht, Utrecht, The Netherlands.
Ned Tijdschr Geneeskd. 2009;153:A387.
Three patients presented with an intoxication caused by Aconitum napellus, commonly known as Aconite, Monkshood or Wolfsbane. The first patient, a woman aged 24, was resuscitated after accidental ingestion of plant material 'from nature'. She experienced severe ventricular tachyarrhythmias. After discharge she returned with identical symptoms, which were now interpreted as intentional intoxication in a suicide attempt. She was referred to the Psychiatry department. The second patient was a 2-year-old boy who had cutaneous exposure to Aconite. Except for some red spots around his mouth there were no other symptoms. The third patient was a 34-year-old woman who ate Monkshood, which she mistook for parsley. Alarmed by the bitter taste she contacted the hospital. She was treated with stomach lavage which removed most of the ingested plant material, and with activated charcoal. She had no symptoms during observation in the hospital. Aconite alkaloids are known to cause ventricular arrhythmia by a prolonged activation of sodium channels. Because there is no antidote, treatment is largely supportive but serious arrhythmias and respiratory arrest need to be anticipated.
三名患者出现了由乌头(俗称附子、草乌或狼毒)中毒的情况。第一名患者是一名24岁的女性,因意外摄入“天然”植物材料而被抢救过来。她经历了严重的室性快速心律失常。出院后,她又出现了相同的症状,现在被认为是自杀未遂的故意中毒。她被转诊到精神科。第二名患者是一名2岁男孩,皮肤接触了乌头。除了嘴周围有一些红点外,没有其他症状。第三名患者是一名34岁的女性,她误将草乌当作欧芹食用。因苦味而警觉后,她联系了医院。她接受了洗胃治疗,洗出了大部分摄入的植物材料,并服用了活性炭。在医院观察期间她没有症状。已知乌头生物碱会通过延长钠通道的激活时间而导致室性心律失常。由于没有解毒剂,治疗主要是支持性的,但需要预见到严重的心律失常和呼吸骤停。