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慢性疼痛且存在物质滥用风险患者的阿片类药物管理。

Management of opioid medications in patients with chronic pain and risk of substance misuse.

机构信息

Dartmouth College, 7764 Parker House, Hanover, NH 03755, USA.

出版信息

Curr Psychiatry Rep. 2009 Oct;11(5):377-84. doi: 10.1007/s11920-009-0057-2.

DOI:10.1007/s11920-009-0057-2
PMID:19785979
Abstract

When prescribed appropriately and used as prescribed, opioid medications can safely and effectively treat pain. Best practices with respect to their use in chronic non-cancer-related pain (CNCP) are evolving. Opioids may be subject to misuse for a variety of purposes, including self-medication, use for reward, compulsive use because of addiction, and diversion for profit. Individuals with chronic pain and co-occurring substance use, mental health disorders, and other conditions may be at increased risk for misuse of prescribed opioids. Interdisciplinary pain management, the use of universal precautions in all patients, and special attention to the structure of care in those at higher risk for opioid misuse may improve outcomes in opioid treatment of CNCP. This article discusses evolving research and clinical literature related to the care of individuals with CNCP at a higher risk for opioid misuse.

摘要

当合理处方和按规定使用时,阿片类药物可以安全有效地治疗疼痛。关于在慢性非癌症相关疼痛(CNCP)中使用的最佳实践正在不断发展。阿片类药物可能会被滥用,其目的包括自我治疗、为了奖励而使用、因为成瘾而强迫使用以及为了盈利而转移。患有慢性疼痛和同时存在物质使用、心理健康障碍和其他疾病的人可能更容易滥用处方阿片类药物。跨学科疼痛管理、在所有患者中使用通用预防措施以及特别关注那些有更高阿片类药物滥用风险的患者的护理结构,可能会改善 CNCP 中阿片类药物治疗的效果。本文讨论了与治疗 CNCP 中具有更高阿片类药物滥用风险的个体相关的不断发展的研究和临床文献。

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Management of opioid medications in patients with chronic pain and risk of substance misuse.慢性疼痛且存在物质滥用风险患者的阿片类药物管理。
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本文引用的文献

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Issues in long-term opioid therapy: unmet needs, risks, and solutions.长期阿片类药物治疗中的问题:未满足的需求、风险及解决方案。
Mayo Clin Proc. 2009 Jul;84(7):593-601. doi: 10.1016/S0025-6196(11)60748-9.
2
Predictors of resolution of aberrant drug behavior in chronic pain patients treated in a structured opioid risk management program.在结构化阿片类药物风险管理项目中接受治疗的慢性疼痛患者异常药物行为缓解的预测因素。
Pain Med. 2009 Jul-Aug;10(5):858-65. doi: 10.1111/j.1526-4637.2009.00643.x. Epub 2009 Jun 11.
3
Methadone as an analgesic for patients with chronic pain in methadone maintenance treatment programs (MMTPs).
一项基于网络的印度执业医师横断面调查,以评估他们对阿片类镇痛药处方的知识、态度、处方习惯及障碍。
Indian J Palliat Care. 2019 Oct-Dec;25(4):567-574. doi: 10.4103/IJPC.IJPC_83_19.
4
Compliance with Opioid Therapy: Distinguishing Clinical Characteristics and Demographics Among Patients with Cancer Pain.癌症疼痛患者阿片类药物治疗依从性的临床特征和人口学差异。
Pain Med. 2018 Jul 1;19(7):1469-1477. doi: 10.1093/pm/pnx178.
5
Anti-nociceptive interactions between opioids and a cannabinoid receptor 2 agonist in inflammatory pain.阿片类药物和大麻素受体 2 激动剂在炎症性疼痛中的抗伤害作用相互作用。
Mol Pain. 2017 Jan-Dec;13:1744806917728227. doi: 10.1177/1744806917728227.
6
Risk Factors for Serious Prescription Opioid-Induced Respiratory Depression or Overdose: Comparison of Commercially Insured and Veterans Health Affairs Populations.严重处方阿片类药物引起的呼吸抑制或过量的风险因素:商业保险和退伍军人健康事务人群的比较。
Pain Med. 2018 Jan 1;19(1):79-96. doi: 10.1093/pm/pnx038.
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Tolerance to the antinociceptive and hypothermic effects of morphine is mediated by multiple isoforms of c-Jun N-terminal kinase.对吗啡的抗伤害感受和体温降低作用的耐受性是由c-Jun氨基末端激酶的多种同工型介导的。
Neuroreport. 2016 Apr 13;27(6):392-6. doi: 10.1097/WNR.0000000000000551.
8
Validation of a brief Opioid Compliance Checklist for patients with chronic pain.慢性疼痛患者简短阿片类药物依从性检查表的验证
J Pain. 2014 Nov;15(11):1092-1101. doi: 10.1016/j.jpain.2014.07.007. Epub 2014 Aug 1.
9
Management of chronic pain with chronic opioid therapy in patients with substance use disorders.物质使用障碍患者慢性阿片类药物治疗慢性疼痛的管理。
Addict Sci Clin Pract. 2013 Dec 16;8(1):21. doi: 10.1186/1940-0640-8-21.
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Long-term opioid treatment of chronic nonmalignant pain: unproven efficacy and neglected safety?长期阿片类药物治疗慢性非恶性疼痛:疗效未经证实且安全性被忽视?
J Pain Res. 2013 Jul 4;6:513-29. doi: 10.2147/JPR.S47182. Print 2013.
美沙酮作为美沙酮维持治疗项目(MMTPs)中慢性疼痛患者的镇痛药。
J Opioid Manag. 2009 Mar-Apr;5(2):107-14. doi: 10.5055/jom.2009.0012.
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Measurement of opioid problems among chronic pain patients in a general medical population.普通医疗人群中慢性疼痛患者阿片类药物问题的测量。
Drug Alcohol Depend. 2009 Sep 1;104(1-2):43-9. doi: 10.1016/j.drugalcdep.2009.03.022. Epub 2009 May 26.
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Opioid induced hyperalgesia: clinical implications for the pain practitioner.阿片类药物诱导的痛觉过敏:对疼痛治疗从业者的临床意义。
Pain Physician. 2009 May-Jun;12(3):679-84.
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Drug Alcohol Depend. 2009 Jul 1;103(1-2):16-24. doi: 10.1016/j.drugalcdep.2009.01.019. Epub 2009 May 2.
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Does report of craving opioid medication predict aberrant drug behavior among chronic pain patients?对阿片类药物的渴望报告能否预测慢性疼痛患者的异常药物行为?
Clin J Pain. 2009 Mar-Apr;25(3):193-8. doi: 10.1097/AJP.0b013e318193a6c4.
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Subtypes of nonmedical prescription drug misuse.非医疗用途处方药滥用的亚型。
Drug Alcohol Depend. 2009 Jun 1;102(1-3):63-70. doi: 10.1016/j.drugalcdep.2009.01.007. Epub 2009 Mar 10.