Department of Psychology, Queens College, The Graduate Center, City University of New York, NY 11367, USA.
Horm Behav. 2010 Jun;58(1):72-81. doi: 10.1016/j.yhbeh.2009.09.012. Epub 2009 Sep 26.
This article reviews sex differences in opiate analgesic and related processes as part of a Special Issue in Hormones and Behavior. The research findings on sex differences are organized in the following manner: (a) systemic opioid analgesia across mu, delta and kappa opioid receptor subtypes and drug efficacy at their respective receptors, (b) effects of the activational and organizational roles of gonadal steroid hormones and estrus phase on systemic analgesic responses, (c) sex differences in spinal opioid analgesia, (d) sex differences in supraspinal opioid analgesia and gonadal hormone effects, (e) the contribution of genetic variance to analgesic sex differences, (f) sex differences in opioid-induced hyperalgesia, (g) sex differences in tolerance and withdrawal-dependence effects, and (h) implications for clinical therapies.
这篇文章回顾了阿片类镇痛药和相关过程中的性别差异，作为《激素与行为》特刊的一部分。关于性别差异的研究结果以以下方式组织：（a）系统阿片类镇痛作用跨越μ、δ和κ阿片受体亚型以及它们各自受体的药物疗效，（b）性腺类固醇激素的激活和组织作用以及发情期对系统镇痛反应的影响，（c）脊髓阿片类镇痛的性别差异，（d） 中脑阿片类镇痛的性别差异和性腺激素的影响，（e）遗传变异对镇痛性别差异的贡献，（f）阿片类药物引起的痛觉过敏的性别差异，（g） 耐受和戒断依赖效应的性别差异，以及（h）对临床治疗的影响。
