维库溴铵对一名肾衰竭新生儿的神经肌肉阻滞作用延长。

Prolonged neuromuscular blockade with vecuronium in a neonate with renal failure.

作者信息

Haynes S R, Morton N S

机构信息

Department of Anaesthesia, Royal Hospital for Sick Children, Yorkhill, Glasgow.

出版信息

Anaesthesia. 1990 Sep;45(9):743-5. doi: 10.1111/j.1365-2044.1990.tb14444.x.

DOI:10.1111/j.1365-2044.1990.tb14444.x

PMID:1978607

Abstract

An 11-day-old neonate with renal failure caused by dysplastic kidneys was anaesthetised with thiopentone, vecuronium, nitrous oxide and oxygen, for insertion of a long-term peritoneal dialysis catheter. Complete neuromuscular block of 210 minutes' duration ensued after the initial dose of vecuronium (97 micrograms/kg). Partial block persisted for a further 30 minutes. The prolonged neuromuscular block in this case may have been because of proportionately greater dependence on renal clearance of vecuronium in neonates.

摘要

一名11日龄因肾发育不良导致肾衰竭的新生儿，在接受硫喷妥钠、维库溴铵、氧化亚氮和氧气麻醉后，插入一根长期腹膜透析导管。首次注射维库溴铵（97微克/千克）后，出现了持续210分钟的完全性神经肌肉阻滞。部分阻滞又持续了30分钟。该病例中神经肌肉阻滞时间延长可能是因为新生儿对维库溴铵肾清除率的依赖性相对更大。