Malo J L, Cartier A, Trudeau C, Ghezzo H, Gontovnick L
Department of Chest Medicine, Hôpital du Sacré-Coeur, Montreal, Canada.
Am Rev Respir Dis. 1990 Nov;142(5):1147-52. doi: 10.1164/ajrccm/142.5.1147.
The duration of effect of inhaled formoterol (24 micrograms) was compared with that of a placebo and that of inhaled albuterol (200 micrograms) in 12 adult asthmatic subjects who underwent hyperventilation tests with cold dry air (-20 degrees C) on 4 study days. On the control day, they were subjected to four hyperventilation tests to ensure functional stability. On the 3 remaining days, after a first hyperventilation test, they inhaled placebo, albuterol, or formoterol in randomized, double-blind fashion. The hyperventilation test was repeated 1, 4, and 8 h and, if the blocking effect was still present, 12 and 24 h after the drug had been administered. The dose of hyperventilation of cold air causing a 20% fall in FEV1 (PD20) was interpolated on the dose-response curve. The magnitude of the blocking effect at each time interval on each study day was assessed by comparing the changes in PD20 from baseline with the within-day variability of PD20 (standardized change in PD20). The acute bronchodilator effect was not significantly different as assessed 15 min (21 +/- 14% for albuterol and 18 +/- 18% for formoterol) and 1 h (20 +/- 13% for albuterol and 18 +/- 17% for formoterol) after administering the medication. The duration of the blocking effect, defined as the return to 2 SD from the standardized change in PD20, was significantly more prolonged for formoterol (8.0 +/- 3.4 h) than for albuterol (3.0 +/- 1.7 h) (t = 4.2, p less than 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)
在12名成年哮喘患者中，比较了吸入福莫特罗（24微克）与安慰剂以及吸入沙丁胺醇（200微克）的作用持续时间。这12名患者在4个研究日接受了冷干空气（-20摄氏度）过度通气试验。在对照日，他们接受4次过度通气试验以确保功能稳定。在其余3天，在首次过度通气试验后，他们以随机、双盲方式吸入安慰剂、沙丁胺醇或福莫特罗。在给药后1、4和8小时重复进行过度通气试验，如果阻断作用仍然存在，则在12和24小时后重复。在剂量-反应曲线上推算出使第一秒用力呼气量（FEV1）下降20%的冷空气过度通气剂量（PD20）。通过比较PD20相对于基线的变化与PD20的日内变异性（PD20的标准化变化），评估每个研究日每个时间间隔的阻断作用大小。用药后15分钟（沙丁胺醇为21±14%，福莫特罗为18±18%）和1小时（沙丁胺醇为20±13%，福莫特罗为18±17%）时，评估的急性支气管扩张作用无显著差异。阻断作用的持续时间定义为从PD20的标准化变化恢复到2个标准差，福莫特罗（8.0±3.4小时）比沙丁胺醇（3.0±1.7小时）显著延长（t = 4.2，p＜0.0001）。（摘要截断于250字）
