Services of Neuropsychology, Neurology and Epileptology, Department of Neurology, University Hospital of Strasbourg, Strasbourg, France.
J Neurol Sci. 2009 Dec 15;287(1-2):69-71. doi: 10.1016/j.jns.2009.09.004. Epub 2009 Sep 27.
Limbic encephalitis (LE) associated with glutamic acid decarboxylase antibodies (GAD-Ab) is rare. We describe a 30-year-old male with acute LE and GAD-Ab, with follow-up during 2 years of cognitive status including verbal episodic memory, number of seizures recorded by high-resolution video-EEG, brain MRI, 2-[18F]-fluoro-2-deoxyglucose PET and GAD-Ab titres. Treatment with corticosteroids, IV immunoglobulins, immunosuppressors and antiepileptic drugs resulted in improved memory status, disappearance of seizures and decreased GAD-Ab titres. Review of the other cases of literature and this case is in favour of the existence of autoimmune LE associated with GAD-Ab and supports the link between memory, temporal seizures and possibly GAD-Ab titres.
伴谷氨酸脱羧酶抗体（GAD-Ab）的边缘性脑炎（LE）罕见。我们描述了一例 30 岁男性急性 LE 和 GAD-Ab，在 2 年的认知状态随访中包括语言情景记忆、高分辨率视频脑电图记录的癫痫发作次数、脑 MRI、2-[18F]-氟-2-脱氧葡萄糖 PET 和 GAD-Ab 滴度。皮质类固醇、IV 免疫球蛋白、免疫抑制剂和抗癫痫药物的治疗导致记忆状态改善、癫痫发作消失和 GAD-Ab 滴度降低。对其他文献病例的回顾和本病例支持存在与 GAD-Ab 相关的自身免疫性 LE，并支持记忆、颞叶癫痫发作和可能的 GAD-Ab 滴度之间的联系。
