Veterans Health Administration's Substance Use Disorders Quality Enhancement Research Initiative, Minneapolis VA Medical Center, Minneapolis, MN 55417, USA.
Drug Alcohol Depend. 2010 Feb 1;107(1):39-43. doi: 10.1016/j.drugalcdep.2009.09.004. Epub 2009 Sep 27.
The objectives of this study were to assess the prevalence of prognostic factors previously known to be associated with poor antibody response to hepatitis B vaccination in a sample of veterans presenting for substance use disorders treatment at a Veterans Health Administration (VA) Medical Center, assess vaccination response, and identify markers for poor response in this population. Results indicated that most participants had multiple prognostic factors previously known to be associated with poor antibody response including male gender, age over 40, smoking, and obesity. The rate of seroconversion in this sample was 51.9%. This is substantially lower than seen in healthy adults. Alcohol dependence was the only significant independent negative predictor of seroconversion in this sample. Substance use disorders treatment providers who are considering adding hepatitis B vaccination services to their clinics should be aware that the antibody response to the hepatitis B vaccination is inconsistent and that patients with particular demographic characteristics may be at heightened risk of poor antibody response.
本研究旨在评估在退伍军人医疗保健管理局（VA）医疗中心就诊的物质使用障碍患者样本中，先前已知与乙型肝炎疫苗接种抗体反应不良相关的预后因素的流行率，评估疫苗接种反应，并确定该人群中不良反应的标志物。结果表明，大多数参与者具有多个先前已知与抗体反应不良相关的预后因素，包括男性、年龄超过 40 岁、吸烟和肥胖。该样本的血清转化率为 51.9%。这远低于健康成年人的水平。在该样本中，酒精依赖是血清转化率唯一显著的独立负预测因子。考虑在诊所中增加乙型肝炎疫苗接种服务的物质使用障碍治疗提供者应该意识到，乙型肝炎疫苗接种的抗体反应不一致，并且具有特定人口统计学特征的患者可能面临不良抗体反应的风险增加。
