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本文引用的文献

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Selenium and anticarcinogenesis: underlying mechanisms.硒与抗癌作用：潜在机制
Curr Opin Clin Nutr Metab Care. 2008 Nov;11(6):718-26. doi: 10.1097/MCO.0b013e3283139674.
2
A trial of the effect of micronutrient supplementation on treatment outcome, T cell counts, morbidity, and mortality in adults with pulmonary tuberculosis.一项关于补充微量营养素对成人肺结核治疗效果、T细胞计数、发病率及死亡率影响的试验。
J Infect Dis. 2008 Jun 1;197(11):1499-505. doi: 10.1086/587846.
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Should micronutrient supplementation be integrated into the case management of tuberculosis?
J Infect Dis. 2008 Jun 1;197(11):1487-9. doi: 10.1086/587847.
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Creation and characterisation of a high-copy-number version of the pAL5000 mycobacterial replicon.pAL5000分枝杆菌复制子高拷贝数版本的构建与特性分析
Tuberculosis (Edinb). 2007 Nov;87(6):481-8. doi: 10.1016/j.tube.2007.08.003. Epub 2007 Sep 20.
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Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide.硒代半胱氨酸β-裂解酶和甲基硒醇脱甲基酶在甲基化硒化合物代谢为硒化物的过程中发挥作用。
Biochim Biophys Acta. 2007 Jul;1770(7):1053-61. doi: 10.1016/j.bbagen.2007.03.007. Epub 2007 Mar 23.
6
The Global Plan to Stop TB, 2006-2015. actions for life: towards a world free of tuberculosis.《2006-2015年全球控制结核病规划：为生命采取行动，努力实现无结核病世界》
Int J Tuberc Lung Dis. 2006 Mar;10(3):240-1.
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Chemical forms of selenium for cancer prevention.用于癌症预防的硒的化学形态。
J Trace Elem Med Biol. 2005;19(2-3):141-50. doi: 10.1016/j.jtemb.2005.09.003. Epub 2005 Oct 24.
8
Altered expression profile of mycobacterial surface glycopeptidolipids following treatment with the antifungal azole inhibitors econazole and clotrimazole.抗真菌唑类抑制剂益康唑和克霉唑处理后分枝杆菌表面糖肽脂的表达谱改变。
Microbiology (Reading). 2005 Jun;151(Pt 6):2087-2095. doi: 10.1099/mic.0.27938-0.
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Stationary phase gene expression of Mycobacterium tuberculosis following a progressive nutrient depletion: a model for persistent organisms?结核分枝杆菌在营养逐渐耗尽后的稳定期基因表达：一种持续性细菌的模型？
Tuberculosis (Edinb). 2004;84(3-4):228-38. doi: 10.1016/j.tube.2003.12.010.
10
Visualisation of zebrafish infection by GFP-labelled Vibrio anguillarum.通过绿色荧光蛋白标记的鳗弧菌观察斑马鱼感染情况。
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改变化学文库筛选中的培养条件可鉴定分枝杆菌的替代抑制剂。

Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria.

机构信息

School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand.

出版信息

Antimicrob Agents Chemother. 2009 Dec;53(12):5279-83. doi: 10.1128/AAC.00803-09. Epub 2009 Sep 28.

DOI:10.1128/AAC.00803-09
PMID:19786608
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2786345/
Abstract

In this study, application of a dual absorbance/fluorescence assay to a chemical library screen identified several previously unknown inhibitors of mycobacteria. In addition, growth conditions had a significant effect on the activity profile of the library. Some inhibitors such as Se-methylselenocysteine were detected only when screening was performed under nutrient-limited culture conditions as opposed to nutrient-rich culture conditions. We propose that multiple culture condition library screening is required for complete inhibitory profiling and for maximal antimycobacterial compound detection.

摘要

在这项研究中，应用双吸收/荧光测定法对化学文库进行筛选，鉴定出了几种以前未知的分枝杆菌抑制剂。此外，生长条件对文库的活性谱有显著影响。一些抑制剂，如硒代蛋氨酸，只有在营养有限的培养条件下进行筛选时才能被检测到，而不是在营养丰富的培养条件下。我们提出，需要进行多种培养条件的文库筛选，以进行完整的抑制谱分析和最大限度地检测抗分枝杆菌化合物。