用于预测新生儿呼吸窘迫综合征的TDx-FLM II特定孕周截断水平。
Gestational age-specific cutoff levels of TDx-FLM II for the prediction of neonatal respiratory distress syndrome.
作者信息
Bennasar Mar, Figueras Francesc, Palacio Montse, Bellart Jordi, Casals Elena, Figueras Josep, Coll Oriol, Gratacós Eduard
机构信息
Department of Maternal-Fetal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques Augusto Pi i Sunyer, University of Barcelona, and Centro de Investigación Biomédica en Red de Enfermedades Raras, Barcelona, Spain.
出版信息
Fetal Diagn Ther. 2009;25(4):392-6. doi: 10.1159/000236152. Epub 2009 Sep 29.
AIM
To construct a predictive model for respiratory distress syndrome (RDS) from gestational age (GA) at delivery and TDx-FLM II value.
METHODS
Pregnant women who underwent an amniocentesis in which TDx-FLM II was determined were included in the study. A model for the occurrence of RDS was constructed by means of a logistic regression procedure from TDx-FLM II values and GA at delivery.
RESULTS
The mean value of TDx-FLM II was 47.11 mg/g. The mean GA at delivery was 33.4 weeks. The incidence of RDS was 7.8% (18/231). The optimal cutoff of predicted risk for respiratory distress was found to be 8.8%, resulting in a sensitivity and specificity of 89 and 83%, respectively.
CONCLUSIONS
The adjustment of the TDx-FLM II value for GA at delivery results in a significant improvement in the predictive capacity of the test for the occurrence of RDS. The use of GA-specific cutoff values may simplify clinical decisions.
目的
根据分娩时的孕周（GA）和TDx-FLM II值构建呼吸窘迫综合征（RDS）的预测模型。
方法
本研究纳入了接受羊膜穿刺术并测定TDx-FLM II的孕妇。通过逻辑回归程序，根据TDx-FLM II值和分娩时的孕周构建RDS发生模型。
结果
TDx-FLM II的平均值为47.11mg/g。分娩时的平均孕周为33.4周。RDS的发生率为7.8%（18/231）。发现呼吸窘迫预测风险的最佳临界值为8.8%，敏感性和特异性分别为89%和83%。
结论
根据分娩时的孕周调整TDx-FLM II值可显著提高该检测对RDS发生的预测能力。使用特定孕周的临界值可能会简化临床决策。
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