Wedding Ulrich, Wendt Thomas G
Abteilung Palliativmedizin, Klinik für Innere Medizin II, Universitätsklinikum Jena, Jena, Deutschland.
Onkologie. 2009;32 Suppl 3:24-8. doi: 10.1159/000228651. Epub 2009 Sep 25.
Differences in tumorbiology and age-associated changes, such as an impaired functional status and the presence of comorbidities, can result in treatment decisions differing from established standards, as standard treatments have often been established through clinical trials mainly including younger patients. Neither therapeutic nihilism due to advanced age nor treatment according to established standards at all costs is the optimal treatment for elderly patients. This article summarizes recently published data regarding the treatment of elderly patients according to main tumor types.
肿瘤生物学差异以及与年龄相关的变化，如功能状态受损和合并症的存在，可能导致治疗决策不同于既定标准，因为标准治疗通常是通过主要纳入年轻患者的临床试验确定的。对于老年患者而言，既不应因年龄偏大而采取治疗虚无主义，也不应不惜一切代价按照既定标准进行治疗。本文总结了最近发表的关于根据主要肿瘤类型治疗老年患者的数据。
