Suárez-Peñaranda Jose Manuel, Vieites Begoña, Valeiras Ernestina, Varela-Duran Juan
Department of Pathology, University Hospital and School of Medicine, Santiago de Compostela, Spain.
Am J Dermatopathol. 2010 Feb;32(1):61-4. doi: 10.1097/DAD.0b013e3181ad4f08.
Primary mucoepidermoid carcinoma (MEC) of the skin is an unusual neoplasm with few cases reported in the English medical literature. It has to be differentiated from adenosquamous carcinoma, usually a high-grade neoplasm with poorer outcome, and metastasis from a primary MEC arising elsewhere in the body. We report a 78-year-old woman with an abdominal skin lesion of recent onset. Histopathological examination revealed a dermal located carcinoma with variable proportions of squamous differentiation and goblet cells. The patient died in a very short time for an unrelated disease. Immunohistochemical study showed staining for cytokeratins (AE1AE3, 7, and 34betaE12), epithelial membrane antigen (EMA), and p63, whereas cytokeratins 18 and 20 and gross cystic disease fluid protein (GCDFP15) were negative. We conclude that primary MEC of the skin is usually a slow-growing neoplasm that should be differentiated from adenosquamous carcinoma. The immunohistochemical staining for p63 is helpful to differentiate primary and metastatic MEC in the skin.
原发性皮肤黏液表皮样癌（MEC）是一种罕见的肿瘤，英文医学文献中报道的病例很少。它必须与腺鳞癌相鉴别，腺鳞癌通常是一种高级别肿瘤，预后较差，还需与身体其他部位原发的MEC转移灶相鉴别。我们报告了一名78岁近期出现腹部皮肤病变的女性。组织病理学检查显示为位于真皮的癌，具有不同比例的鳞状分化和杯状细胞。该患者因 unrelated disease 在很短时间内死亡。免疫组化研究显示细胞角蛋白（AE1AE3、7和34βE12）、上皮膜抗原（EMA）和p63呈阳性，而细胞角蛋白18和20以及大囊性病液蛋白（GCDFP15）呈阴性。我们得出结论，原发性皮肤MEC通常是一种生长缓慢的肿瘤，应与腺鳞癌相鉴别。p63的免疫组化染色有助于鉴别皮肤原发性和转移性MEC。
