Central Laboratory (Pest) of Semmelweis University, H-1083 Budapest, Hungary.
Eur J Gastroenterol Hepatol. 2010 Feb;22(2):185-91. doi: 10.1097/MEG.0b013e3283316219.
We tested the hypothesis whether trace elements and antioxidant status change in a sex-dependent manner may contribute to sex-dependent hepatic effects of moderate daily wine consumption.
Twenty-one healthy young men and women were enrolled to this study who consumed red wine 0.3 and 0.2 l per day, respectively, for a month. Blood was taken at baseline (BV) and at end of the study (EV). Red cell trace element levels, red cell and plasma antioxidant status and serum routine blood chemistry were assessed at baseline and at the end of the study.
No sign of hepatotoxicity was detected. BV level of some trace elements (i.e. Zn, Pb) and Zn/Cu ratios were higher in women than in men. Ca, Mg, Pb, Sr and Zn levels and the Zn/Cu ratio had lower EV than BV in women. In men, Al, Ca, Li, Pb and Sr levels had lower EV than BV. The tested antioxidant parameters improved in both the sexes.
Although no hepatotoxicity was observed, changes in trace element content were detected after 1 month of moderate red wine consumption. The most remarkable sex-specific alteration was the decrease of Zn levels and of the Zn/Cu ratio in women. Given the protective effect of Zn against liver damage, this finding suggests a possible contribution of decreased Zn levels to sex-dependent effects of red wine.
我们检验了这样一个假设，即微量元素和抗氧化状态是否会以性别依赖的方式发生变化，从而可能导致适度日常饮酒对肝脏产生性别依赖性影响。
本研究纳入了 21 名健康的年轻男性和女性，他们分别每天饮用红葡萄酒 0.3 和 0.2 升，持续一个月。在基线（BV）和研究结束时（EV）采集血液。在基线和研究结束时评估红细胞微量元素水平、红细胞和血浆抗氧化状态以及血清常规血液化学。
未检测到肝毒性迹象。女性的一些微量元素（如 Zn、Pb）和 Zn/Cu 比值高于男性。女性的 EV 比 BV 更低的元素包括 Ca、Mg、Pb、Sr 和 Zn 水平以及 Zn/Cu 比值。男性的 Al、Ca、Li、Pb 和 Sr 水平的 EV 比 BV 更低。所有测试的抗氧化参数在两性中均有所改善。
尽管未观察到肝毒性，但在适度饮用红葡萄酒 1 个月后，检测到微量元素含量发生了变化。最显著的性别特异性变化是女性 Zn 水平和 Zn/Cu 比值降低。鉴于 Zn 对肝损伤具有保护作用，这一发现提示 Zn 水平降低可能对红葡萄酒的性别依赖性影响有一定贡献。
