Department of Social Medicine, Post-graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Int J Obes (Lond). 2010 Jan;34(1):195-202. doi: 10.1038/ijo.2009.201. Epub 2009 Sep 29.
Rapid weight gain in childhood may increase the risk of chronic adult diseases. Few studies have examined the effects of lifecourse weight gain on waist circumference (WC), hip circumference (HC), or waist-to-hip ratio (WHR).
To evaluate the effects of birthweight and weight gain from birth to age 23 years on WC, HC, and WHR in young adults.
Population-based birth cohort study started in 1982. A sample of 856 individuals was examined in 2006. Conditional growth analyses were carried out with adjustment for confounders. WC and HC were also mutually adjusted.
Weight gains during all age ranges studied (birthweight, 0-2, 2-4, 4-15, 15-18/19, and 18/19-23 years) were positively associated with WC and HC in both sexes. These effects were strongest from 4 to 15 years range (beta = 5.0 cm for both circumferences). Proxies for visceral adipose tissue (WHR and WC adjusted for HC) were associated with weight gain after 2 years in females and after 4 years in males. Subcutaneous adipose and muscular tissues, assessed by HC adjusted for WC, were associated with birthweight and weight gain from 0 to 2 years in both sexes, and again with weight gains from 4 to 18 years in males and 4 to 15 years in females.
Weight gains in utero and in the first 2 years had long-term effects on HC, but weight gain after age 4 years was strongly associated with WC. Weight gains up to age 2 years may reduce cardiovascular risk associated with adult fat patterns in a middle-income setting.
儿童期体重快速增加可能会增加成年后慢性疾病的风险。很少有研究探讨一生中体重增加对腰围（WC）、臀围（HC）或腰臀比（WHR）的影响。
评估出生体重和 23 岁前的体重增加对年轻成年人 WC、HC 和 WHR 的影响。
基于人群的出生队列研究于 1982 年开始。2006 年对 856 名个体进行了检查。在调整混杂因素后进行了条件增长分析。还对 WC 和 HC 进行了相互调整。
研究期间所有年龄段（出生体重、0-2 岁、2-4 岁、4-15 岁、15-18/19 岁和 18/19-23 岁）的体重增加均与男女 WC 和 HC 呈正相关。这些影响在 4 至 15 岁年龄段最强（两个周长的增加均为 5.0 厘米）。在女性中，2 年后和男性中 4 年后，内脏脂肪组织（WC 调整后的 WHR 和 WC）的代表物与体重增加相关。在女性中，由 WC 调整后的 HC 评估的皮下脂肪和肌肉组织与出生体重和 0 至 2 岁的体重增加相关，在男性中，与 4 至 18 岁的体重增加相关，在女性中，与 4 至 15 岁的体重增加相关。
子宫内和 2 岁前的体重增加对 HC 有长期影响，但 4 岁后体重增加与 WC 密切相关。2 岁前的体重增加可能会降低中低收入人群中与成年脂肪模式相关的心血管风险。
