Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.
Eur J Clin Nutr. 2013 Nov;67(11):1147-53. doi: 10.1038/ejcn.2013.183. Epub 2013 Oct 2.
To evaluate the relationship between birth weight and rapid weight gain in infancy and markers of overweight/obesity in childhood, using different cutoff values for rapid weight gain.
SUBJECTS/METHODS: Cross-sectional study involving 98 5-year old pre-school Brazilian children. Rapid weight gain was considered as weight gain in standard deviation score (SDS) above +0.67, +1 and +2 in relation to birth weight, at any time during the first 2 years of life. The nutritional status of the children was determined by anthropometry and electrical bioimpedance. Multiple linear regression analysis was used, considering fat mass percentage, body mass index (BMI), waist and neck circumferences as outcomes.
Birth weight, rapid weight gain (assessed by different cutoff values) and maternal obesity were positively associated with increased fat mass percentage, BMI, waist and neck circumferences. Different cutoff values of rapid weight gain did not change the positive associations between rapid weight gain and fat mass percentage (>+0.67 SDS, P=0.007; >+1 SDS, P=0.007; >+2 SDS, P=0.01), BMI (>+0.67 SDS, P=0.002; >+1 SDS, P=0.007; >+2 SDS, P<0.001), waist circumference (>+0.67 SDS, P=0.002; >+1 SDS, P=0.002; >+2 SDS, P<0.001) and neck circumference (>+0.67 SDS, P=0.01; >+1 SDS, P=0.03; >+2 SDS, P<0.001).
The use of different cutoff values for the definition of rapid weight gain did not interfere in the associations between birth weight and rapid weight gain with fat mass percentage, BMI, waist and neck circumferences. Children with the highest birth weight, those who undergo rapid weight gain in infancy and whose mothers were obese, seemed to be more at risk for overweight/obesity.
使用不同的快速体重增长（Rapid Weight Gain，RWG）定义临界值来评估婴儿期出生体重与快速体重增长和儿童超重/肥胖标志物之间的关系。
对象/方法：这是一项涉及 98 名 5 岁巴西学龄前儿童的横断面研究。快速体重增长被定义为出生体重后第 1 年内任何时间的体重增长超过标准偏差评分（SDS）+0.67、+1 和+2。儿童的营养状况通过人体测量和生物电阻抗法来确定。使用多元线性回归分析，将体脂百分比、体重指数（BMI）、腰围和颈围作为结果。
出生体重、快速体重增长（通过不同的临界值评估）和母亲肥胖与体脂百分比、BMI、腰围和颈围的增加呈正相关。不同的快速体重增长临界值并未改变快速体重增长与体脂百分比（>+0.67 SDS，P=0.007；>+1 SDS，P=0.007；>+2 SDS，P=0.01）、BMI（>+0.67 SDS，P=0.002；>+1 SDS，P=0.007；>+2 SDS，P<0.001）、腰围（>+0.67 SDS，P=0.002；>+1 SDS，P=0.002；>+2 SDS，P<0.001）和颈围（>+0.67 SDS，P=0.01；>+1 SDS，P=0.03；>+2 SDS，P<0.001）之间的正相关关系。
使用不同的快速体重增长定义临界值不会干扰出生体重与快速体重增长与体脂百分比、BMI、腰围和颈围之间的关系。出生体重最高、婴儿期快速体重增长且母亲肥胖的儿童似乎超重/肥胖的风险更高。
