University Department of Urology, Zagreb, Croatia.
Prostate Cancer Prostatic Dis. 2010 Mar;13(1):78-82. doi: 10.1038/pcan.2009.43. Epub 2009 Sep 29.
Syndecans are a four-member family of transmembrane heparan sulphate proteoglycans that have different functions in cell signalling, adhesion, cytoskeleton organization, migration, proliferation, and angiogenesis. Several studies investigated the role of syndecan-2 (SDC2) in different carcinomas; however, only one being focused on SDC2 in prostate cancer. SDC2 expression and relationship with established prognostic features were assessed in a cohort of 86 patients treated with radical prostatectomy for clinically localized prostate adenocarcinoma. SDC2 expression was present in the majority of prostate cancers and absent in only 11.6% of cases. SDC2 expression was also recorded in cells of prostatic intraepithelial neoplasia, whereas normal prostatic epithelial tissue and stroma did not express SDC2. SDC2 overexpression in prostate cancer was significantly associated with established features indicative of worse prognosis such as higher preoperative PSA (P=0.011), higher Gleason score (P<0.001), positive surgical margins (P<0.003), and extraprostatic extension of disease (P<0.003). Moreover, expression of SDC2 was also associated with biochemical disease progression on univariate analysis (P<0.001). Study results supported the potential role of SDC2 in prostatic carcinogenesis and cancer progression. Moreover, SDC2 could serve as an additional prognostic marker that might help in further stratifying the risk of disease progression in patients with prostate cancer.
黏附素是一个由四个成员组成的跨膜硫酸乙酰肝素蛋白聚糖家族，在细胞信号转导、黏附、细胞骨架组织、迁移、增殖和血管生成中具有不同的功能。多项研究调查了黏附素-2 (SDC2) 在不同癌症中的作用；然而，只有一项研究集中在前列腺癌中的 SDC2。在 86 例接受根治性前列腺切除术治疗局限性前列腺腺癌的患者队列中，评估了 SDC2 的表达及其与既定预后特征的关系。SDC2 表达存在于大多数前列腺癌中，只有 11.6%的病例不存在。SDC2 表达也记录在前列腺上皮内瘤变的细胞中，而正常前列腺上皮组织和基质不表达 SDC2。前列腺癌中 SDC2 的过度表达与术前 PSA 较高（P=0.011）、Gleason 评分较高（P<0.001）、手术切缘阳性（P<0.003）和疾病的前列腺外扩展（P<0.003）等预示预后不良的既定特征显著相关。此外，在单因素分析中，SDC2 的表达也与生化疾病进展相关（P<0.001）。研究结果支持 SDC2 在前列腺癌发生和癌症进展中的潜在作用。此外，SDC2 可以作为一个额外的预后标志物，有助于进一步分层前列腺癌患者疾病进展的风险。
