Rosenfeld Simon, Kapetanovic Izet
DHHS/NIH/National Cancer Institute/Division of Cancer Prevention, EPN, 6130 Executive Blvd, Bethesda, MD 20892, USA.
Gene Regul Syst Bio. 2008 Oct 10;2:307-19. doi: 10.4137/grsb.s1114.
In this paper, we outline the status quo and approaches to further development of the systems biology concepts with focus on applications in cancer prevention science. We discuss the biological aspects of cancer research that are of primary importance in cancer prevention, motivations for their mathematical modeling and some recent advances in computational oncology. We also make an attempt to outline in big conceptual terms the contours of future work aimed at creation of large-scale computational and informational infrastructure for using as a routine tool in cancer prevention science and decision making.
在本文中，我们概述了系统生物学概念的现状以及进一步发展的方法，重点是在癌症预防科学中的应用。我们讨论了癌症研究中对癌症预防至关重要的生物学方面、对其进行数学建模的动机以及计算肿瘤学的一些最新进展。我们还试图从宏观概念上勾勒未来工作的轮廓，旨在创建大规模的计算和信息基础设施，用作癌症预防科学和决策中的常规工具。
