基于超灵敏 DNA zyme 的比色核酸检测策略。
An ultrasensitive DNAzyme-based colorimetric strategy for nucleic acid detection.
机构信息
Department of Chemical and Biomolecular Engineering, KAIST, Daejeon 305-701, Korea.
出版信息
Chem Commun (Camb). 2009 Oct 21(39):5838-40. doi: 10.1039/b907762f. Epub 2009 Jun 19.
DOI:10.1039/b907762f
PMID:19787114
Abstract
An ultrasensitive DNAzyme-based colorimetric DNA detection strategy was developed by utilizing gold nanoparticles modified with both peroxidase-mimicking DNAzymes and capture DNAs and magnetic nanoparticles modified with another capture DNAs, with a detection limit for a model Chlamydia gene of 50 fM.
摘要
基于 DNA zyme 的超灵敏比色 DNA 检测策略是通过利用同时修饰有过氧化物酶模拟 DNAzyme 和捕获 DNA 的金纳米颗粒以及另一个修饰有捕获 DNA 的磁性纳米颗粒来开发的，该策略对模型衣原体基因的检测限为 50 fM。
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