Istituto Ortopedico Rizzoli, Bologna, Italy.
Knee Surg Sports Traumatol Arthrosc. 2010 Aug;18(8):1052-8. doi: 10.1007/s00167-009-0925-7. Epub 2009 Sep 29.
The purpose of the present study was to make a histological analysis of the remodelling process of hamstring tendon graft used as Anterior Cruciate Ligament (ACL). The hamstring graft of eight patients was biopsied at different follow-up times from 1 to 10 years. The specimens were analysed with transmission electron microscopy (TEM) at ultrastructural level comparing them with a native ACL and a native hamstring graft. The hamstring graft was found to undergo ultrastructural changes in terms of number and diameter of fibrils with the major changes occurring in the first 2 years. At longer times after surgery (48 and 120 months) no important further changes were evident and the ultrastructure did not vary substantially from 2 to 10 years. In conclusion, the hamstring tendon used as ACL graft undergoes a transformation process but does not match the ultrastructure pattern of a normal ACL up to 10 years.
本研究的目的是对作为前交叉韧带 (ACL) 的腘绳肌腱移植物的重塑过程进行组织学分析。8 名患者的腘绳肌腱移植物在 1 至 10 年的不同随访时间进行了活检。使用透射电子显微镜 (TEM) 在超微结构水平对标本进行分析，并与天然 ACL 和天然腘绳肌腱移植物进行比较。结果发现，腘绳肌腱的纤维数量和直径发生了超微结构变化，主要变化发生在最初的 2 年内。手术后更长时间（48 和 120 个月）后，没有明显的进一步变化，超微结构在 2 至 10 年内没有明显差异。总之，用作 ACL 移植物的腘绳肌腱经历了一个转化过程，但在 10 年内并未达到正常 ACL 的超微结构模式。
