对产前暴露于可卡因及其他药物的儿童的睡眠问题进行母亲报告的纵向研究。
Longitudinal study of maternal report of sleep problems in children with prenatal exposure to cocaine and other drugs.
作者信息
Stone Kristen C, High Pamela C, Miller-Loncar Cynthia L, Lagasse Linda L, Lester Barry M
机构信息
Brown Center for the Study of Children at Risk, Women & Infants Hospital, 101 Dudley St., Providence, RI 02905, USA.
出版信息
Behav Sleep Med. 2009;7(4):196-207. doi: 10.1080/15402000903190108.
Sleep data were collected by maternal report in a prospective longitudinal follow up of cocaine-exposed and unexposed children. There were 139 participants: 23 with no prenatal drug exposure, 55 exposed to cocaine alone or in combination with other drugs, and 61 exposed to drugs other than cocaine. Characteristics differed between exposure groups including birth size, caretaker changes, maternal socioeconomic status, and postnatal drug use. Compared to those with no drug exposure, children with prenatal drug exposure other than cocaine experienced greater sleep problems (p = .026). Prenatal nicotine exposure was a unique predictor of sleep problems (p = .048). Early sleep problems predicted later sleep problems (all ps < .01). Together, these preliminary findings suggest possible neurotoxic sleep effects that persist over time. Larger studies, however, need to be conducted that better control for potential postnatal confounding factors.
在一项对可卡因暴露和未暴露儿童的前瞻性纵向随访中，通过母亲报告收集睡眠数据。共有139名参与者：23名无产前药物暴露，55名仅暴露于可卡因或同时暴露于其他药物，61名暴露于可卡因以外的药物。暴露组之间的特征存在差异，包括出生体重、照顾者变更、母亲社会经济地位和产后药物使用情况。与无药物暴露的儿童相比，产前暴露于可卡因以外药物的儿童睡眠问题更多（p = 0.026）。产前尼古丁暴露是睡眠问题的一个独特预测因素（p = 0.048）。早期睡眠问题可预测后期睡眠问题（所有p值均<0.01）。这些初步研究结果共同表明，可能存在随着时间持续的神经毒性睡眠效应。然而，需要进行更大规模的研究，以更好地控制潜在的产后混杂因素。
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