Roy A, Berrettini W, DeJong J, Adinoff B, Ravitz B, Linnoila M
Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD.
Psychiatry Res. 1990 Sep;33(3):215-9. doi: 10.1016/0165-1781(90)90038-7.
Neuropeptide Y is found in brain tissue. In dogs it has been shown to enhance activation of the hypothalamic-pituitary-adrenal axis by corticotropin-releasing hormone. It is localized in certain catecholamine neurons and to some extent colocalized with somatostatin. Disturbances of the central noradrenergic system may underlie some forms of alcoholism. Therefore, we compared male alcoholics and normal controls on cerebrospinal fluid (CSF) levels of neuropeptide Y. There was no significant difference between the two groups for neuropeptide Y. There was also no significant difference for CSF levels of growth hormone releasing hormone. However, there were significant positive correlations between CSF levels of neuropeptide Y and CSF levels of corticotropin-releasing hormone, somatostatin, and growth hormone releasing hormone.
神经肽Y存在于脑组织中。在狗身上已表明它能增强促肾上腺皮质激素释放激素对下丘脑-垂体-肾上腺轴的激活作用。它定位于某些儿茶酚胺能神经元，并在一定程度上与生长抑素共定位。中枢去甲肾上腺素能系统的紊乱可能是某些形式酒精中毒的基础。因此，我们比较了男性酗酒者和正常对照者脑脊液中神经肽Y的水平。两组之间神经肽Y水平无显著差异。生长激素释放激素的脑脊液水平也无显著差异。然而，神经肽Y的脑脊液水平与促肾上腺皮质激素释放激素、生长抑素和生长激素释放激素的脑脊液水平之间存在显著正相关。
