DWI e.V. and Institute of Technical and Macromolecular Chemistry, RWTH Aachen, Aachen, Germany.
Small. 2009 Dec;5(23):2756-60. doi: 10.1002/smll.200901313.
A simple, soft nanolithographic method is used to fabricate sub-10-nm structures on star polyethylene glycol-based hydrogels and perfluoropolyether-based materials. Very small features, for example, gold nanoparticles of size approximately 8 nm with an interparticle distance of approximately 100 nm, are successfully reproduced from a hard silicon master into both elastomers. Scanning force microscopy is used to investigate the replicas, and the original hexagonal pattern of the nanoparticles is clearly recognized. In addition, both replicas are usable as secondary, soft molds yielding positive copies of the primary, hard master. The results presented here show similar replication capabilities for both elastomers despite the markedly different properties of the precursors. Moreover, the hydrogel material can be easily peeled off from both soft and silicon masters without the need for surface treatment. The procedure allows nanopatterning of a biocompatible material over large areas, which is a useful tool to investigate cellular responses to defined nanotopography.
一种简单的软纳米光刻方法被用于在星形聚乙二醇水凝胶和全氟聚醚材料上制造小于 10nm 的结构。非常小的特征，例如尺寸约为 8nm 且颗粒间距离约为 100nm 的金纳米颗粒，成功地从硬硅模具复制到两种弹性体中。扫描力显微镜用于研究复制品，并且可以清楚地识别出纳米颗粒的原始六边形图案。此外，两种复制品都可用作二级软模具，产生原始硬模具的正副本。尽管前体的性质明显不同，但这里呈现的结果表明两种弹性体都具有相似的复制能力。此外，水凝胶材料可以很容易地从软模具和硅模具上剥离下来，而无需表面处理。该方法允许在大面积上对生物相容性材料进行纳米图案化，这是一种有用的工具，可以研究细胞对定义的纳米形貌的反应。
