转化生长因子-β（TGFβ）信号传导的故事：一个精致的谜团。
The tale of transforming growth factor-beta (TGFbeta) signaling: a soigné enigma.
作者信息
Chaudhury Arindam, Howe Philip H
机构信息
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
出版信息
IUBMB Life. 2009 Oct;61(10):929-39. doi: 10.1002/iub.239.
Abstract
Transforming growth factor-beta (TGFbeta) is a secreted cytokine, which intricately controls a plethora of physiological and pathological processes during development and carcinogenesis. TGFbeta exerts antiproliferative effects and functions as a tumor suppressor during early stages of tumorigenesis, whereas at later stages it functions as a tumor promoter aiding in metastatic progression through an autocrine TGFbeta loop. Intricate knowledge of TGFbeta signaling and its regulation are still evolving. In this review, we make an attempt to showcase the associated enigma of TGFbeta signaling in its dual functional role as tumor suppressor and metastatic promoter during early and late stages of carcinogenesis, respectively.
摘要
转化生长因子-β（TGFβ）是一种分泌型细胞因子，在发育和致癌过程中复杂地控制着众多生理和病理过程。TGFβ发挥抗增殖作用，在肿瘤发生的早期阶段作为肿瘤抑制因子发挥作用，而在后期阶段它作为肿瘤促进因子，通过自分泌TGFβ环促进转移进展。对TGFβ信号及其调控的深入了解仍在不断发展。在本综述中，我们试图展示TGFβ信号在致癌作用的早期和晚期分别作为肿瘤抑制因子和转移促进因子的双重功能作用中相关的谜团。
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