De Nitto Daniela, Monteleone Ivan, Franzè Eleonora, Pallone Francesco, Monteleone Giovanni
World J Gastroenterol. 2009 Oct 7;15(37):4609-14. doi: 10.3748/wjg.15.4609.
Celiac disease (CD), an enteropathy caused by dietary gluten in genetically susceptible individuals, is histologically characterized by villous atrophy, crypt cell hyperplasia, and increased number of intra-epithelial lymphocytes. The nature of CD pathogenesis remains unclear, but recent evidence indicates that both innate and adaptive immune responses are necessary for the phenotypic expression and pathologic changes characteristic of CD. Extensive studies of molecules produced by immune cells in the gut of CD patients have led to identification of two cytokines, namely interleukin (IL)-15 and IL-21, which are thought to play a major role in orchestrating the mucosal inflammatory response in CD. Here we review the current knowledge of the expression and function of IL-15 and IL-21 in CD.
乳糜泻（CD）是一种由遗传易感个体摄入膳食麸质引起的肠病，其组织学特征为绒毛萎缩、隐窝细胞增生和上皮内淋巴细胞数量增加。CD发病机制的本质尚不清楚，但最近的证据表明，先天性和适应性免疫反应对于CD的表型表达和病理变化都是必需的。对CD患者肠道中免疫细胞产生的分子进行的广泛研究，已导致鉴定出两种细胞因子，即白细胞介素（IL）-15和IL-21，它们被认为在协调CD中的粘膜炎症反应中起主要作用。在此，我们综述了目前关于IL-15和IL-21在CD中的表达和功能的知识。
